A series of 13 novel 3-hydroxyindolin-2-one-benzo[4,5]imidazo[2,1-b]thiazole hybrids was designed, synthesized, and evaluated as potential anti-Alzheimer agents targeting monoamine oxidase B (MAO-B) and cholinesterases. The target compounds were obtained by condensing a benzo[4,5]imidazo[2,1-b]thiazole-based ketone wit...
Wagdy M. Eldehna, Ashraf K. El-Damasy, Jaeyeop Lim et al.· RSC Advances· 0 citations
The development of innovative treatment medicines that can overcome drug resistance and intracellular persistence is necessary since tuberculosis (TB) continues to be a significant worldwide health burden. In this work, series of hybrid compounds containing azole moieties, imine/semicarbazide linkers, and isonicotinoyl...
Wagdy M. Eldehna, Zainab M. Elsayed, M. Korycka-Machała et al.· RSC Medicinal Chemistry· 0 citations
The ongoing emergence of SARS-CoV-2 mutations underscores the urgent need for new antivirals that target key viral proteins. This study describes the design, synthesis, and evaluation of two series of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as inhibitors of the SARS-CoV-2 main protease (Mpro): 1,2,3-tria...
T. Al-Warhi, Md Sofequl Islam Mukim, Zainab M. Elsayed et al.· RSC Advances· 0 citations
The consistent binding of compound 5 d within the ATP‐binding pocket of CDK‐2 was confirmed by molecular docking and molecular dynamics simulations, and attractive drug‐like and pharmacokinetic features, similar to those of Roscovitine, were demonstrated by in silico ADMET predictions.
Wagdy M. Eldehna, Zainab M. Elsayed, Mohamed R. Elnagar et al.· Drug development research (P...· 0 citations
