Author

Zexiang Han

2 papers indexed here

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Open access Sep 2026

Charge-driven remodelling of monomeric Tau determines its phase behaviour

Tau transitions from a functional microtubule-stabilising monomer into pathological aggregates in tauopathies. However, the molecular mechanism by which soluble Tau transitions into insoluble aggregates remains poorly understood. Here, we show that modulation of Tau’s internal charge-charge interactions by pH and ionic...

Yudisthira Oktaviandie, Ze-Xiang Han, Katherine Stott et al. · bioRxiv · 0 citations

#protein folding Open access Aug 2026

Quantifying molecular specificity in excipient-driven antibody solubilization

It is shown that excipient-mediated solubilization of therapeutic antibodies is markedly molecularly specific, and the integration of high-throughput experimentation with molecular feature analysis offers a foundation for improving the understanding and prediction of antibody-specific formulation behavior.

Zexiang Han, Nadia A. Erkamp, Rob M. Scrutton et al. · mAbs · 0 citations