Development and optimization of a cell cycle molecular clock based on the ABE-CRISPR system.
The adenine base editor template number (ATN) system is developed, which implements ordered, stepwise editing of double-stranded DNA through a programmable cascade of modifications and enables temporally regulated manipulation of cell fate.
Xin-Yuan Dai, Jia-Chuan Jin, Zhao-Jun Wang et al.
· Journal of genetics and geno... · 0 citations