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Background The PD‐1/PD‐L1 axis plays a critical role in suppressing T‐cell activation and facilitating immune evasion in lung adenocarcinoma (LUAD). This study focused on PD‐1‐related genes to develop a robust prognostic prediction model for LUAD. Methods Immune scores were calculated using the ESTIMATE algorithm, and...
Highlights • Single-cell transcriptomics reveals epithelial heterogeneity shaping NSCLC immunity.• A 101-algorithm ML framework constructs a Prognostic and Immunotherapeutic Signature.• PIS stratifies NSCLC patients by prognosis and immune checkpoint blockade response.• ADAM12 inhibition enhances anti-PD-1 efficacy in...
It is found that PAX5, a neural/lymphatic transcription factor, contributed to neuroendocrine (NE) lineage transition, and targeting PAX5 and its downstream signaling may modulate lineage transitions responsible for treatment failure in both SCNCs and adenocarcinomas.
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