Open access
Aug 2026
Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage
It is demonstrated that colonic macrophage-mediated extracellular matrix (ECM) remodeling orchestrates enteric neuronal maturation and dictates colitis progression and the m6Am machinery is illuminated as a promising therapeutic target for preventing neuronal loss in IBD patients.
Chen-Bo Ding, Jia-Cheng Zhao, Tian-Hua Zhao et al.
· Cellular & Molecular Immunol... · 0 citations