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Author

Zhi-Hang Shen

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Open access Sep 2026

Cryo-EM structure-based discovery of etravirine as a specific inhibitor of PRMT5/pICln protein-protein interaction for prostate cancer treatment

It is demonstrated that the unique P4I interface is a promising therapeutic target and that etravirine serves as a proof-of-concept lead compound for exploring the potential of P4I-targeted strategies in prostate cancer.

Zhi-Xia Chi, Xue-Yong Xu, Zhi-Hang Shen et al. · 0 citations
Review Jul 2026

Protein arginine methyltransferases as regulators of phase separation: implications in cancer and neurodegenerative diseases.

A review of PRMTs as key modulators of phase separation and potential therapeutic targets in both oncology and neurodegeneration highlights PRMTs as key modulators of phase separation and potential therapeutic targets.

Zhi-Hang Shen, Qiu-Bin Yu · 0 citations

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