Protein arginine methyltransferases as regulators of phase separation: implications in cancer and neurodegenerative diseases.

S-Adenosylmethionine-Dependent Methylation, Protein Arginine Methyltransferases and Cardiovascular Diseases

Methylation, catalyzed by a diverse family of S-adenosylmethionine (SAM)-dependent methyltransferases, is a fundamental biochemical process that regulates the function of proteins, DNA, and RNA. Among these modifications, protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), represents...

Protein arginine methyltransferases in cardiovascular disease: mechanisms, therapeutic potential, and future directions

Protein arginine methyltransferases (PRMTs) constitute a family of nine enzymes that catalyze the post-translational methylation of arginine residues on histone and non-histone proteins. This epigenetic modification regulates diverse cellular processes including gene transcription, RNA splicing, signal transduction, an...

RBM protein family: Focusing on the occurrence, progression and treatment of cancer

Reciprocal regulation of m6A RNA methylation and protein post-translational modifications: implications for disease pathogenesis and therapy.

A framework for understanding the regulatory networks of m6A-PTMs crosstalk in disease pathogenesis, development, and therapeutic response is provided, highlighting potential treatment strategies based on this interplay and suggesting future research directions.

Arginine methylation in immunoregulation: Mechanisms and therapeutic targeting.

Post-translational modifications (PTMs) are central regulators of immune cell function, linking extracellular signals to the regulation of intracellular gene expression. Among these, protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is a key mechanism that connects epigenetic contr...

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential

Empirical evidence elucidating how m6A regulators remodel cystine import, GPX4-dependent antioxidant defense, FSP1 signaling, lipid metabolism, iron handling, autophagy and tumor-microenvironmental communication is synthesized.