Base editing-mediated induction of stop codons in HPV18 E6/E7 for cervical cancer therapy.
Persistent infection with high-risk human papillomaviruses (hrHPVs) is a primary driver of cervical carcinogenesis, with the viral oncogenes E6 and E7 playing pivotal roles. Conventional nuclease-based gene-editing strategies are limited by genome-wide off-target effects and genomic perturbations associated with double...
Yue Kang, Yi-Fan Wu, Bing-Ting Bao et al.
· Molecular Therapy · 0 citations