Author

Zhong-Can Ou-Yang

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Open access Sep 2026

Entropy-Driven Initiation and Cytoskeletal Viscoelasticity in Endocytosis: An Onsager Variational Framework

Receptor-mediated endocytosis requires a particle to approach the cell membrane to within a few nanometers before ligand–receptor binding can occur. Existing continuum models often start from an already established contact and do not explicitly describe how crowding particles on the extracellular side influence the dis...

Jin-Jie Liu, Zhong-Can Ou-Yang, Hao Wu · Membranes · 0 citations

Preprint Jul 2026

Entropy-Driven Initiation and Cellular Uptake Mediated by Viscoelastic Cytoskeleton: A Kinetic Phase Diagram from Onsager Variational Principle

A fundamental question in receptor-mediated endocytosis remains unanswered: what initial driving force brings ligands and receptors into close proximity? While previous models assume pre-existing contact and overlook this initiation problem, we propose that entropic forces from nanoscale biomolecules in crowded cellula...

Jin-Jie Liu, Zhong-Can Ou-Yang, Hao Wu · 1 citation