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Author

Ziqing Yuan

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Open access Sep 2026

A Tri-Phasic View of the Microenvironment in Breast Cancer Brain Metastasis

Breast cancer brain metastasis (BCBM) is driven by microenvironmental remodeling across three interconnected phases: the primary tumor microenvironment (TME) licenses dissemination, the pre-metastatic niche (PMN) primes the brain, and the established metastatic niche sustains outgrowth through central nervous system (C...

Zi-Qing Yuan, Yan-Qing Wu, Yue Zhao et al. · 0 citations
Review Open access Aug 2026

Tumor Immunotherapy Resistance: Underlying Mechanisms and Emerging Strategies to Overcome Therapeutic Bottlenecks

This review presents a systematic synthesis of the principal tumor immunotherapy strategies and their corresponding resistance mechanisms, finding that combination therapies and personalized treatment strategies grounded in TME profiling and biomarkers represent critical future directions.

Ziqing Yuan, Chen-Xi Zhou, Shaoquan Zheng et al. · 0 citations

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