Safety benchmarks for large language models often assess the risk of a user query, although the outcome of question answering depends on whether the response violates a policy. This distinction is critical in Chinese harmful-content evaluation, where linguistic variation and adversarial transformations can obscure risky intent. We introduce C-SafeQA, a policy-grounded benchmark for response-level Chinese safety evaluation. It comprises 538 base queries and 8,877 adversarial queries answered by four full-model LLM deployments, yielding 37,660 query-response records labeled safe, unsafe, or disputed. Reference labels are generated through agreement-aware multi-model adjudication and blind audits of stratified subsets by three safety experts. C-SafeQA supports both evaluation of target-model safety and auditing of seven automated safety judges against shared reference labels. Unsafe-response rates range from 0.93% to 3.35% on base queries and from 11.68% to 30.05% on adversarial queries. On the adversarial subset, judges show substantial trade-offs between unsafe-response recall and risk-query-conditioned safe-response false positive rate, and no judge dominates all metrics. Both acrostic transformations reduce unsafe recall for all seven judges, revealing mechanism-specific evaluator weaknesses. Dataset records, metadata, verification code, and judge scripts are publicly released to support recomputation, while benchmark construction, target-response generation, and private adjudication remain outside the release boundary.
Rui Yang, Shuang Huang, Junhua Liu et al.· 0 citations
Crystal generators and tool-using agents propose structures faster than density functional theory (DFT) energy and phonon calculations or experiments can assess them. Deciding which candidates merit expensive assessment is therefore the bottleneck, yet most screens test little beyond atomic overlap and give no chemical reason for failure. Here, our agents generate, test and actively refute two million candidate laws, leaving eight Plausibility Rules for Inorganic Structures (PRIS). These laws encode five mechanisms: short-range repulsion, ionic contact and packing, electrostatic balance, bond-valence conservation and crystallographic site complexity. Experimental structures satisfy our law sets at 82--99%, but satisfy Pauling's rules 2--5 together at only 6.5%. The strictest set detects 87.9% of damaged crystal structures, whereas distance cutoffs detect only 1.6--3.2%. PRIS plausibility is linearly correlated with synthesizability, so the PRIS-derived synthesis score (PSS) explainably screens 83.7% of hard-to-synthesize structures while retaining 80.7% of experimental structures. In a property-conditioned inverse-design run, PRIS and PSS can reduce the DFT validation queue by up to 67.3% and keep 99.2% of the candidates whose DFT-validated bulk moduli reach the design target. Beyond screening, PRIS explains why GNoME remains enriched in rare low-symmetry structures and reveals how wrong-element assignments in falsified crystal reports hide behind plausible coordinates. PRIS moves screening from a pass-or-fail verdict to a chemical reason for failure, showing that autonomous agents can discover, by active refutation, physicochemical laws that guide calculations and experiments.
Clinical trials are essential for advancing cancer care and drug development, but many fail because of insufficient patient enrollment. While there is growing interest in using AI to support patient recruitment, existing systems largely perform eligibility assessment alone and have rarely been evaluated in real-world oncology workflows. Here we present TrialGPT 2.0, an AI-assisted clinical trial recommendation system designed for real-world deployment. Rather than asking only whether a patient may qualify, the system also assesses which trials warrant further consideration given the patient's current clinical needs and local workflow priorities, and provides structured, inspectable explanations for expert review. Importantly, we evaluated TrialGPT 2.0 retrospectively and prospectively across multiple oncology-focused settings, spanning government, academic cancer-center, patient-advocacy, and NIH referral workflows. In retrospective multicenter cohorts comprising 288 cases, TrialGPT 2.0 retrieved at least one clinician-recommended trial in its top 10 recommendations for approximately 91% of cases while reducing clinician screening time by 55.0%. In a six-month prospective evaluation embedded in an active precision oncology tumor board, TrialGPT 2.0 contributed additional trial opportunities missed by the routine workflow, expanding patient access to clinical trial participation by 90.9%. To support scientific reproducibility, we also introduce NIH-TrialBench, a clinician-authored dataset comprising 126 diverse synthetic patient vignettes and matching scenarios from 11 NIH Institutes and Centers. Together, these results support the value of AI to assist clinical trial matching by improving clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.
Yin Fang, Qiao Jin, Shubo Tian et al.· 0 citations
A single vulnerability in a widely used library can cascade through millions of dependent applications, yet more than half of vulnerability database entries contain missing or incorrect affected-library information. Existing automated approaches neglect the relational structure of vulnerability databases, treating identification as an isolated text retrieval problem. In this paper, we propose Athena, the first graph-based approach for vulnerability affected library identification. Athena models vulnerability databases as a knowledge graph and reformulates the identification problem as knowledge graph completion (KGC). It comprises three key modules: a Modeling module that constructs a security knowledge graph integrating CVEs, libraries, CWE weakness types, CPE products, and software ecosystems; a Completion module that applies a modular KGC backbone to predict missing affected libraries for a given CVE via link prediction; and a Re-ranking module that retrieves KGC candidates and rescores them using a fine-tuned LLM augmented with knowledge graph embeddings, jointly leveraging structural and textual information. Our experiments on VulLib demonstrate that Athena significantly outperforms four state-of-the-art baselines, achieving a 32% improvement in Avg. F1 over the best baseline (i.e., VulLibGen). Notably, our KGC backbone with only 110M parameters already surpasses VulLibGen's best configuration at 7B parameters, demonstrating the effectiveness of graph-based modeling; the re-ranking module then provides substantial further gains, consistently outperforming the best baseline across all evaluated LLM backbones.
Autoencoders typically meet tight latent-memory budgets by making each latent representation smaller, sacrificing representational capacity. We ask a different question: can multiple wider latents be stored together instead? We introduce the Superposed Latent Autoencoder (SLAE), which preserves high-capacity latent representations while sharing storage through learned superposition. SLAE transforms latents into storage-friendly codes, binds them with randomized keys, superposes multiple codes into a single memory tensor, and learns to recover each latent before decoding. Under the same storage budget, SLAE replaces irreversible dimensional bottlenecks with structured interference that can be suppressed. Across CIFAR-10/100, SVHN, STL-10, Tiny ImageNet, and a wide range of memory budgets, SLAE substantially improves the reconstruction--memory tradeoff, reducing reconstruction error by up to 56% over conventional autoencoders at matched storage. Further analysis shows that SLAE's advantage comes from making wider representations usable under the same storage budget. These gains also extend beyond reconstruction: the information preserved by SLAE improves downstream classification by up to 16.79 percentage points under the same memory budget. Our results suggest a new principle for representation compression: instead of making every latent smaller, keep representations wide and let them share memory.
Quanling Zhao, Jiaying Yang, Tianqi Zhang et al.· 0 citations
Stain normalization reduces color variations caused by variations in staining protocols and imaging conditions, thereby enhancing computer-aided diagnostic system performance. Traditional methods derive mapping relationships from individual or limited reference images through pixel-wise transformation, offering style flexibility but suffering from inaccurate color mapping extraction. While existing deep-learning-based approaches achieve accurate dataset-wide color mapping through complex neural networks, they face challenges including computational inefficiency, artifact generation, and fixed normalization directions requiring model retraining for directional changes. To address these limitations, we propose StainPresetNet - a novel framework that combines structural preservation with dataset-level color mapping while maintaining computational efficiency. Our method implements pixel-wise normalization guided by preset reference images, enabling multi-directional adaptability without retraining. Evaluations on cytopathology and histopathology datasets demonstrate that StainPresetNet achieves superior color mapping accuracy compared to conventional methods, effectively improves classifier generalization in diagnostic tasks, and reduces computational overhead by 90\% versus existing deep learning approaches. The proposed preset-guided mechanism facilitates flexible adjustment of normalization directions through simple reference image replacement, overcoming the directional rigidity of current deep-learning-based solutions.
Hongtao Kang, Die Luo, Li Chen et al.· 0 citations
Past literature on face recognition for monozygotic (("identical") twins points to facial marks and mirror asymmetry as possible directions for improved accuracy of twins recognition. The Celeb Twins Test Set (CTTS) contains web-scraped image pairs for 80 sets of celebrity twins. It is the only twins test set with meta-data for twins with distinguishing skin marks and possible mirror asymmetry. CTTS is organized in the manner of face verification test sets such as LFW, CALFW, CPLFW, CFP-FP, and AgeDB-30. Current deep CNN matchers can achieve over 76% accuracy in classifying CTTS same-person / different-person image pairs. We show that current matchers do not make use of skin marks, or asymmetry, and discuss reasons for this. Finally, we discuss the feasibility of using generative AI tools such as Grok, ChatGPT and Gemini to create images of imagined monozygotic twins as a means to increase representation of twins in face recognition training sets.
Michael Zang, Haiyu Wu, M. Sharma et al.· 0 citations
Early recognition of lane-change intention is essential for proactive decision-making in autonomous driving and advanced driver assistance systems. This paper proposes a Dual Neural-Calibrated Interacting Multiple Model (DNC-IMM) that improves adaptability to driving context while preserving the probabilistic structure and interpretability of a conventional IMM. The proposed method encodes driving-context information, including target-vehicle motion, gaps to surrounding vehicles, and relative velocities, with a neural network that calibrates both the transition-probability matrix and measurement likelihoods. The final intention is determined from the calibrated IMM mode posterior rather than from a separate direct classifier. Experiments on the highD dataset demonstrate that the proposed method reliably recognizes lane-change intentions before lane crossing and provides particularly strong performance at the earlier 2-3 s prediction horizons.
Dialectal Arabic (DA) remains under-resourced compared to Modern Standard Arabic (MSA), particularly for machine reading comprehension (MRC) and question answering (QA). Existing Arabic QA benchmarks primarily focus on formal written MSA or multiple-choice QA, with limited coverage of naturally spoken dialects. Here, we aim to bridge this gap. We introduce EDRAC, the first large-scale benchmark for dialectal Arabic machine reading comprehension (MRC) and generative QA, covering five major dialects: Egyptian, Moroccan, Emirati, Syrian, and Saudi Arabic. EDRAC contains 499 passages derived from naturally occurring spoken interactions and 4,977 corresponding QA pairs generated through a human--LLM collaborative pipeline combining iterative generation, LLM-as-a-judge evaluation, and human verification. We benchmark Arabic-centric and multilingual LLMs on EDRAC using lexical and semantic metrics. Our results reveal substantial gaps between semantic answer quality and dialectal fidelity, highlighting the limitations of existing evaluation metrics for dialectal Arabic generation. EDRAC provides a realistic and challenging MRC benchmark for future research on dialectal Arabic NLP.
Noor Abo Mokh, Kirill Chirkunov, Teresa Lynn et al.· 0 citations
When a hint turns a failing generated program into a passing one, does it provide missing information or merely steer the model toward a solution it could already produce? We test these hypotheses on HumanEval+ and MBPP+ using executable evaluation. For Qwen2.5-3B-Instruct, adaptive relevant hints rescue 36 of 79 selected failures; an unrelated hint rescues 19, while eight unhinted samples solve 46 and recover 31 of the 36 relevant-hint rescues. Phi-3.5-mini shows the same pattern: relevant hints rescue 42 of 101 failures, an unrelated hint rescues 17, and unhinted sampling solves 57, including 36 of the 42 relevant-hint rescues. Because the hint conditions use different attempt budgets, these comparisons do not isolate a purely semantic effect. Mechanistic tests on Qwen identify a stable activation direction shared by relevant and unrelated hints. Persistently adding this direction yields 14 rescues and 18 regressions, with no detectable net accuracy gain; learned low-rank interventions have a positive but imprecise estimated effect. Full textual specifications solve 22 of 24 context-defined problems, versus 5-11 for tested virtual-KV prefixes. Post-generation hidden-state probes transfer across benchmarks, with pooled AUROC 0.806 and 0.780, but their top-one selection advantage over token confidence is statistically unresolved. Overall, relevant hints can rescue failures, but most rescued solutions are already reachable through ordinary sampling, and the internal interventions tested here do not establish task-general capability transfer.
Large language models often answer the same multiple-choice question inconsistently when it is posed under support-oriented and elimination-oriented framings. We investigate whether these discrepancies arise from different internal representations induced by the two framings. We introduce a dual-framing protocol with minimally varied prompts that use either support- or elimination-oriented framing while keeping the evaluation target fixed. To probe the internal computation, we append an untrained special token, [STATE], and treat its residual-stream activation as an intervention interface. Across both models, the two framings induce separable [STATE] activations concentrated in intermediate layers. Swapping these activations between paired prompts systematically changes predictions and improves cross-framing agreement, providing intervention-based evidence that the activations are behaviorally relevant. Beyond instance-level substitution, mean-difference steering directions derived from the dual-framing contrast exhibit more bounded layer-wise responses than matched contrastive activation addition directions under the evaluated protocol.
Chao Gao, Haijiang Liu, Qiyuan Li et al.· 0 citations
Crystal generators can now propose periodic structures, but their control interfaces remain poorly matched to the mixed descriptors used in materials design. Text provides a compact way to combine composition, symmetry, prototype and property cues, yet it has not been clear whether such information can steer flow-based crystal generation. Here we introduce TFMat, a text-conditioned flow-matching framework that uses structured materials language as a semantic prior for a CrystalFlow generator. Across Perov-5, Carbon-24 and MP-20 crystal structure prediction benchmarks, TFMat improves one-candidate match rates over CrystalFlow and reaches a 92.04% MP-20 match rate with 20 candidates; in de novo generation, it improves element-count and density distribution alignment while retaining coarse property consistency in composition-selected outputs. These results position structured text as an inspectable control layer for translating human-readable materials intent into candidate crystals for downstream simulation and validation.
