gene editing

Beyond Earth: Recent Advancements in Microgravity Biomedical and Genetic Research in Saudi Arabia

Recent advances in genetic and biomedical research under microgravity conditions are summarized, with particular emphasis on molecular mechanisms, omics technologies, genome editing, microbiome research, regenerative medicine, and personalized healthcare approaches.

Brassinosteroids as Central Regulators of Plant Growth, Stress Tolerance, and Agricultural Resilience

Overall, BRs represent promising targets for improving crop stress resilience; however, optimizing BR-mediated strategies and validating their long-term performance under diverse field conditions will be essential for their successful application in sustainable agriculture.

From the Microscope to the Genome: A New Era in the Molecular Genetics of Epidermolysis Bullosa

Overall, this review synthesizes the molecular basis of all four major EB types across 16+ classical genes, highlights the paradigm shift where NGS achieves a diagnostic yield exceeding 90%, and critically assesses recent therapeutic milestones—ranging from the first FDA-approved topical gene therapy to precision RNA a...

CRISPR–Cas technologies for precision genome editing in plants: advances, applications, and future perspectives

This review provides a comprehensive synthesis of a recent advances in CRISPR–Cas technologies and their strategic applications in crop genetics and hybrid breeding, and showcases how these technologies accelerate hybrid breeding by engineering male sterility systems, fixing heterosis, and generating high-throughput mu...

CRISPR/Cas9-Mediated Editing of Bsr-d1 and Pi21 Enhances Blast Resistance in a High-Quality Rice Maintainer Line

Rice (Oryza sativa L.) is a staple food crop worldwide, and improving disease resistance is a core target in rice breeding. In this study, we employed CRISPR/Cas9 genome editing to modify the coding sequence (CDS) of two susceptibility genes, Bsr-d1 and Pi21, in the elite maintainer line Gengxiang B to enhance its blas...

Mitogenome assembly and phylogenetic relationships of Phalaris arundinacea

Comparative analysis of non-synonymous-to-synonymous substitution rate (Ka/Ks) ratios across divergent species revealed that the mitochondrial genome of P. arundinacea underwent stabilizing evolutionary dynamics, characterized by predominant purifying selection with several lineage-specific variations in selective pres...

U.S. consumers’ processing of information about CRISPR-edited pork products

ABSTRACT The commercialization of CRISPR gene-edited pork is advancing rapidly, following the U.S. Food and Drug Administration’s approval of gene-edited pigs resistant to Porcine Reproductive and Respiratory Syndrome (PRRS). As these products move closer to market entry, understanding how consumers seek, process, and...

Exploring the role of CRISPR in advancing space biotechnology: challenges and solutions for human survival beyond earth

This review comprehensively examines the potential applications of CRISPR in space biotechnology, focusing on enhancing astronaut health by targeting genes associated with muscle atrophy, bone loss, radiation resistance, and immune function and the use of CRISPR-engineered microorganisms to support closed-loop life-sup...

Genomics and crop improvement: focus on gene editing and its regulation

The future of crop improvement using GEd technologies lies in the harmonisation or alignment of global policies and regulations to support the trade of agricultural produce and ensure that growers and consumers can benefit from GEd technology.

Zhang Q, Wu Y, Yang J, et al. Viral vector-free generation of orthogonal IL-2–responsive CAR T cells through gene editing of IL-2 and its receptor. Blood Immunol Cell Ther. 2025;1(3):100019.

Osteogenesis Imperfecta from Historical Nosology to Gene-directed Therapy: A Critical Narrative Review of Mechanism, Evidence and Translational Uncertainty

Evaluating critically how historical nosology, molecular pathology and emerging gene-directed interventions relate to one another is evaluated, and to determine which conclusions the accessible evidence can currently sustain are evaluated.

Unravelling DNA: Applying Christian Values to a Genetic Age

The author did an excellent job of explaining these technologies in language that anyone could understand, and showing why they are important and relevant by giving specific examples, and I thought Wild did an excellent job of explaining these technologies in language that anyone could understand.