gene editing

Correction to “Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress”

Genomic architecture of hereditary defects in beef cattle populations: from molecular diagnostics to innovative therapy approaches (review)

Recommendations are formulated for building a genetic health management system in beef cattle breeding, based on mandatory DNA testing, inbreeding control, accounting for pleiotropic effects in selection, and the integration of advanced biotechnologies.

CRISPR/Cas9-Induced Dwarfism in Barley: Impacts on Yield-Related Traits and Root Architecture

These results provide new insights into HvDEP1′s role in both shoot and root systems and demonstrate that precise CRISPR/Cas9-mediated editing can rapidly introduce dwarfism while revealing trade-offs in other agronomic traits.

Cryptomeria japonica var. sinensis Miquel (Chinese Cedar): A Comprehensive Review of Its Biology, Phytochemistry, Biotechnology, and Utilization

This review provides a comprehensive foundation for understanding the biology, phytochemistry, biotechnology, and utilization of this invaluable botanical resource, offering a strategic roadmap for its sustainable management and commercial valorization.

Navigating Quality, Safety, and Analytical Testing Frameworks for Viral Vector–Based Gene Editing Therapies

This article aims to provide a working framework for verifying the potency, genomic integrity, and clinical safety of vector-based gene therapies—one intended to be useful both to laboratories developing these products and to those responsible for regulating them.

Comparative chloroplast genomics of six Bupleurum (Apiaceae) accessions: candidate barcodes, phylogeny based on available plastomes, and candidate RNA-editing sites

The whole-plastome phylogeny recovered Bupleurum as monophyletic relative to Chamaesium, and only one of seven multi-accession operational binomial groups was monophyletic, and only one showed a positive local barcode gap.

Long-term in vivo CRISPR/Cas9 gene editing in liver triggers host immunity and clonal mutations in DNA damage response genes beyond off-target effects.

Integrating Multi-Omics in Aquaculture: From Genetic Gains to Sustainable Aquaculture

This review outlines foundational applications of omics in aquaculture and highlights the characteristics and current applications of distinct omics approaches, and summarizes three core application domains of omics in aquaculture.

Establishment of a CRISPR/Cas9-mediated system for targeted editing of the MFS gene in mint

A substantial decrease in menthofuran content in the essential oil of the edited line #10 compared to the wild-type control is revealed, thereby demonstrating a viable strategy for improving mint essential oil quality through genome-editing.

Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche

It is argued that formation of a tumour-intrinsic niche is a prerequisite for BRAF-mutant CRC seeding to distant organs and that interference with niche formation may help avoid metastatic relapse.

An Explicit Interaction-Prompted Diffusion Framework for High-Fidelity 3D Molecular Generation.

Current structure-based drug design generative models often struggle to faithfully recapitulate genuine ligand-protein binding interactions. Instead, under the coupling of implicit learning architectures and biased training data, they tend to learn spurious statistical correlations. To address this, we propose EIP-Diff...

Universal CAR-T cell therapy: mechanisms and evasion strategies of bidirectional immune rejection.

This review systematically delineates the mechanisms underlying bidirectional immune rejection and comprehensively summarizes state-of-the-art mitigation strategies and highlights the development of alternative, inherently hypoimmunogenic cell sources as a fundamental approach to circumventing these immunological barri...