AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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1,774 papers
This optimized PE system substantially enhances PE efficiency in Cucurbit crops, providing an effective solution to common challenges such as low editing efficiency and limited heritability in these species.
This review summarizes recent progress in elucidating plant virus-vector molecular interactions and their potential use in innovative strategies for virus and vector control.
An RNA-guided bridge recombinase system is engineered through rational mutagenesis and AI-assisted directed evolution, enabling programmable chromosomal rearrangements in both plant and mammalian cells and achieving up to a 29.8-fold increase in activity.
Compared with conventional homologous recombination, the CRISPR-Cas9 system substantially improved gene disruption efficiency, thereby overcoming a major limitation in the genetic manipulation of lichen-forming fungi.
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This first-in-human study demonstrated the feasibility of an "off-the-shelf" base-edited CAR T cell approach and informs future multiantigen strategies against AML.
Cell-specific epigenetic editing holds very high therapeutic value for atherosclerosis, cardiomyopathy, and fibrosis, provided that delivery, specificity, and safety challenges are also addressed.
This synthesis provides a framework for translating mechanistic hormonal insights into field-applicable cultivars to ensure global food security and proposes a systems-level roadmap for developing climate-resilient rice cultivars capable of maintaining yield stability across a volatile combinatorial stress landscape.
Results indicate that targeted reactivation of BFL-1 and SQOR increases cell-death susceptibility in liver cancer cells, providing proof-of-concept for locus-specific epigenetic therapy in liver cancer.
This targeted modification markedly improved rice eating and cooking quality while maintaining the levels of total starch, total protein, and key agronomic traits.
The gene-edited mFD-PEVs reprogram redox homeostasis in NPCs, regulate ferroptosis, and promote intervertebral disc regeneration.
Post-training alignment is often shallow, eroding under fine-tuning. It remains untested as to whether constitutional midtraining interventions can produce durable alignment when cleanly isolated from post-training. We build a 394M-token constitutional corpus from Anthropic's Constitution and apply constitutional midtr...
It is demonstrated that local nucleosome sequence and structure profoundly influence Cas nuclease accessibility and specificity, with HIFIv1 emerging as the top-performing nuclease for nucleosomal targets, while evoSpCas9 excelled in exposed contexts.
Host Sowbhagya Suresh shares some of the latest news and cutting-edge research from across Microsoft—from understanding the challenges facing coding agents to uncovering how people use AI at work and improving extended-range weather forecasting. The post Microsoft Research Focus – Edition #97 appeared first on Microsoft Research.
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
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A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
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