gene editing

Clean gene technology for precision breeding and genetic improvement of vegetable crops

Worldwide demand for vegetable production is accelerating due to population growth and increasing health awareness. Although traditional plant breeding is successful for vegetable production, it is time-consuming and constrained by sexual compatibility. The emergence of transgenic technology has provided a breakthrough...

Digital Genome Workstation: interactive and non-destructive editing of genome variants

Genome-variant analysis is commonly organized as linear pipelines for annotation, filtering, and prioritization. Digital Genome Workstation (DGW) complements these workflows with a local desktop environment for interactively constructing, editing, and comparing alternative diploid variant configurations derived from a...

A highly efficient detached-leaf transient expression system and endogenous promoter toolkit for advancing gene functional analysis and gene editing in Cymbidium

transient expression system and endogenous promoter toolkit for advancing gene functional analysis and gene editing in Cymbidium, aBIOTECH,

A Qualitative and Quantitative Detection Method for Gene Editor Residues Based on Cutting-Edge Biosensing Technology

This study focuses on the core pain points of the current gene editing industry, specifically addressing the residual editor issue arising from the widespread application of CRISPR/Cas9 technology. A novel, highly sensitive method for the qualitative and quantitative detection of residual Cas9 has been developed, which...

Editing cells in place: Targeted in vivo gene editing of hematopoietic stem cells.

Traditional ex vivo hematopoietic stem cell (HSC) gene therapy faces manufacturing challenges. A recent study1 in Nature Biomedical Engineering demonstrates that antibody-engineered lipid nanoparticles achieve efficient and durable in vivo editing of HSCs in humanized mice, offering a promising therapeutic strategy for...

The utilitarian temptation in gene editing.

Identification of Novel Regulators of Telomere Length and its Impact on Endothelial Dysfunction

Telomere length (TL) is highly heritable and associated with a plethora of health conditions, including cancer, Alzheimer's and coronary artery disease (CAD). A number of studies have linked TL to CAD, with short TL preceding disease onset. Genetic studies support a causal link between the two, though the mechanism rem...

Gene-Targeted Therapies in Inherited Bone Marrow Failure Syndromes

Inherited bone marrow failure syndromes (IBMFS) are genetically heterogeneous multiorgan disorders sharing defective hematopoiesis and cancer predisposition. Here, we examine emerging strategies to suppress nonsense mutations, with a focus on translational readthrough-inducing drugs (TRIDs), nonsense-mediated decay mod...

Functional Improvement of dystrophic muscle by utrophin gene editing

Streamlining oversight in gene-editing trials.

Digital Genome Workstation: interactive and non-destructive editing of genome variants

Genome-variant analysis is commonly organized as linear pipelines for annotation, filtering, and prioritization. Digital Genome Workstation (DGW) complements these workflows with a local desktop environment for interactively constructing, editing, and comparing alternative diploid variant configurations derived from a...

Reactivation of the embryonic ζ-globin gene ameliorates severe forms of α-thalassemia

Hemoglobinopathies are the most common inherited anemias worldwide. While most carriers are asymptomatic or mildly affected, severe forms of α-thalassemia, including severe hemoglobin H (HbH) disease and surviving individuals with Hb Bart’s hydrops fetalis syndrome (BHFS), require lifelong transfusion support or stem c...