This protocol enables quantification of INDELs and DNA-SVs, allowing for validation of gene disruption, and describes guide RNA (gRNA) design, plasmid cloning, delivery of AAV-CRISPR to the liver, and execution of liver DNA-editing analysis.
K. Jarrett, Rodrigo Baltazar-Nunez, Chloe Anne Borja et al.· STAR Protocols· 0 citations
Tourmaline v2.2.0 This release adds the tax-credit step: a fourth, optional workflow step that benchmarks reference databases and taxonomic classifiers, based on code from Bokulich et al. 2018. Bokulich NA, Kaehler BD, Rideout JR, Dillon M, Bolyen E, Knight R, Huttley GA, Caporaso JG. Optimizing taxonomic classificatio...
Luke Thompson, Katherine Silliman, Luke Thompson et al.· Zenodo (CERN European Organi...· 0 citations
Age at puberty is the earliest indicator of future reproductive potential of a gilt and because it is moderately heritable, identification of genomic markers can support marker-assisted selection to improve gilt development.
C. A. Lents, H. Wijesena, D. Nonneman et al.· Journal of Animal Science· 0 citations
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A three-tiered conceptual framework that operationalizes ethical principles to provide researchers with guidance on whether to initiate first-in-human studies involving gene transfer or genome editing is presented.
Hélène Nobile, Marcel Mertz· Research Ethics· 0 citations
Natural mutations in the prolactin receptor gene (PRLR) result in slick hair phenotype and improved thermoregulation. Gene-editing technologies allow the introduction of novel variants into PRLR, providing a strategy to rapidly incorporate slick phenotype into cattle populations. The objective of this study was to ev...
R. Oliveira, R. Cooke, T. Minela et al.· Journal of Animal Science· 0 citations
Tomato production is increasingly threatened by the growing occurrence and severity of combined drought and high-temperature stress. Although the individual effects of high temperature and drought stress on tomato growth, physiology, and productivity have been widely investigated, their combined occurrence exerts more...
P. R. Athmika, A. Senthil, M. Djanaguiraman et al.· Plant Science Today· 0 citations
What's Changed ZFIN-10433: fetch the PANTHER classifications over HTTPS by @cmpich in https://github.com/ZFIN/zfin/pull/1964 ZFIN-10389: Update journals with ISSNs by @cmpich in https://github.com/ZFIN/zfin/pull/1963 ZFIN-10344 Follow-up: Add parameters to make the switchover easier by @rtaylorzfin in https://github.co...
Christian Pich, Ryan Taylor, zfinryanm et al.· Zenodo (CERN European Organi...· 0 citations
The reproduction workflow and the archived intermediate results for the paper. Everything needed to rebuild the manuscript's tables is here: the code is a snapshot of the trimmed reproduction repository, and the bundles hold the computed intermediates, so a reader does not have to re-derive them. Reproducing from the r...
Chand Sahil Mansuri, Joel Zachariah, Sadamori Kojaku· Zenodo (CERN European Organi...· 0 citations
Genome editing in avian systems has largely relied on plasmid-based CRISPR systems and antibiotic selection to achieve successful editing. However, plasmid delivery can result in prolonged nuclease expression and potential unintended DNA integration. In addition, selection-based enrichment may mask the intrinsic geno...
Sydney G. Bingham, Jin Lee Kim, Kiho Lee et al.· Journal of Animal Science· 0 citations
This Zenodo deposit contains a publicly available description of the Dataset: Title: "iSCORE-PD: NGS genotyping and zygosity testing of isogenic hESC clones". Description: Targeted DNA sequencing data for the iSCORE-PD isogenic hESC clone collection, encompassing three complementary analyses: (1) NGS genotyping of 53 m...
Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed et al.· Zenodo (CERN European Organi...· 0 citations
Antisense oligonucleotides and genome editing can restore transcript fidelity by preventing cryptic exons inclusion in STMN2 and UNC13A, thereby stabilizing neuronal function and improving the lifespan and quality of life of patients with ALS.
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
Exploring how generative AI could make machine vision more accessible to businesses. The post GenEye in a Box: Making Machine Vision Something You Can Just Ask For appeared first on GPT-Lab.
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