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✨ Highlights Fork a session into a new writable copy. A local or imported session can be forked with its complete research history — conversation branches, Notebook records, artifact versions, literature, annotations, and private bookmarks all receive fresh identities. The source session is never altered, and imported...
SpectralKoopman This repository provides an implementation of the Spectral Koopman Approximation (SKA) method for stochastic reaction networks (SRNs). The code accompanies the manuscript: A spectral framework for revealing the hidden low-dimensional structure in stochastic reaction networks Ankit Gupta and Mustafa Kham...
The 33rd Fungal Genetics Conference was held from March 17th to the 22nd at the Asilomar Conference Center in Pacific Grove, California. The conference has been held at Asilomar 24 times since it began as the “Neurospora Information Conference” in 1961. Over meals at the large round tables, it is common for attendees t...
This deposit contains the complete computational model and analysis code for a within-host study of autologous CCR5 gene-edited HIV cure. The work shows that the conversion of a patient's CD4 T cell pool to an HIV-resistant state is rate-limited by the turnover of the patient's own unedited cells rather than by any pro...
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Following the publication of the above article, an interested reader raised several comments on the study that required clarification on the part of the authors in order to confirm the reporting of certain of the results, and to make the paper fully comprehensible. First, in the Materials and methods section, the singl...
The authors are grateful to the Editor of Oncology Reports for granting them this opportunity to publish a Corrigendum, and apologize to both the Editor and the readership for any inconvenience caused.
Results indicate a possible link between transcriptional remodeling, RNA editing, and functional polarization of HCC-induced neutrophils, and provide an exploratory framework for investigating ADAR-regulated RNA editing in tumor-immune communication.
This article systematically reviews the current research landscape of different ncRNAs in HNC at the molecular level and explores the challenges posed by heterogeneity in ncRNA therapy concerning delivery, target selection, and microenvironmental interference.
In vitro studies in an erythroid progenitor cell line and primary CD34+ cells demonstrated that the EPORW439* variant conferred a strong proliferative advantage to therapeutically modified erythroid progenitors, establishing a strategy to amplify the therapeutic benefit of otherwise limited in vivo HSPC gene editing fo...
Plant mitochondrial genomes exhibit remarkable structural plasticity and evolutionary complexity; however, their diversity and evolutionary mechanisms remain poorly understood in many crop lineages. In this study, we systematically characterized the mitochondrial genome structures of Cucumis species to provide new insi...
A minimally humanized mouse model of aniridia, carrying a FLAG-tagged Pax6 and the most common recurring pathogenic aniridia-patient variant, introduced for the first time in mice is generated and tested, supporting successful generation and phenotypic validation of the humanized mouse.
No approach yet combines adequate central nervous system distribution, mutant‐allele selectivity, durable neurological benefit, and established long‐term safety in HD research and development, but no approach yet combines adequate central nervous system distribution, mutant‐allele selectivity, durable neurological bene...
Genie 4: our new world model unlocking unprecedented realism in real-time simulation.
Generative AI
General Science
A Blog post by NVIDIA on Hugging Face
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
General Science
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