Fatty acid composition of milk triacylglycerol (TAG) is important for neonatal growth. We previously identified a synonymous mutation widely distributed in human populations, IGF-1 c.258A > G, which decreased milk TAG content in gene-edited mice. So far, the acyl chain composition of affected TAGs, underlying molecular...
Shuo Zheng, Jia-Yuan Fang, Yi Li et al.· bioRxiv· 0 citations
This review synthesizes recent advances in pharmaco‐microbiomics, reframing cancer treatment in a hologenetic context, with host, tumor and microbiome acting as a tripartite entity, and establishes microbiome as a predictor and therapeutic target in precision medicine.
Hailah M. Almohaimeed, Aniruddha Chatterjee, Sayani Ghosh et al.· Comprehensive Physiology· 0 citations
Recent advances in CRISPR-Cas9–mediated genome editing are highlighted, emphasizing breakthroughs in primary cell editing and the development of translational models for genetic diseases and diabetes mellitus.
Md Nur Islam, Md. Mahmudul Islam, Han Feng et al.· Molecular Biology Reports· 0 citations
It is demonstrated that CHD2 dosage bidirectionally regulates lysosomal function and autophagosome flux to set the tempo of neuronal maturation, and that CHD2 and lysosomal homeostasis constitute a critical molecular axis regulating the pace of cortical development across evolution and disease.
O. Leonardi, E. Lewerissa, Davide Aprile et al.· bioRxiv· 3 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
This review discusses available methods for controlling potyvirus infection in solanaceous crops and proposes that genome editing be routinely used as part of efforts to develop resistant cultivars.
R. Hanisia, Alfred Patisenah, H. A. S. M. P. Negara et al.· Journal of Horticultural Res...· 0 citations
This repository contains the analysis code and demonstration data accompanying the INSCRIBE STAR Protocols manuscript. The workflow processes multiplexed smFISH imaging followed by ratiometric barcode readout in HEK293 cells, integrating gene-expression measurements and barcode editing levels at single-cell resolution....
Kai Hao, Amjad Askary· Zenodo (CERN European Organi...· 0 citations
Myelodysplastic syndromes are clonal hematopoietic stem cell neoplasms characterized by ineffective hematopoiesis and a variable risk of transformation to acute myeloid leukemia. This study examines the potential of CRISPR-Cas9 editing of DNMT3A, TET2, ASXL1, TP53, and SF3B1 to prevent disease progression. A narrative...
T Rufino· Zenodo (CERN European Organi...· 0 citations
This repository contains the analysis code and demonstration data accompanying the INSCRIBE STAR Protocols manuscript. The workflow processes multiplexed smFISH imaging followed by ratiometric barcode readout in HEK293 cells, integrating gene-expression measurements and barcode editing levels at single-cell resolution....
Kai Hao, Amjad Askary· Zenodo (CERN European Organi...· 0 citations
Myelodysplastic syndromes are clonal hematopoietic stem cell neoplasms characterized by ineffective hematopoiesis and a variable risk of transformation to acute myeloid leukemia. This study examines the potential of CRISPR-Cas9 editing of DNMT3A, TET2, ASXL1, TP53, and SF3B1 to prevent disease progression. A narrative...
T Rufino· Zenodo (CERN European Organi...· 0 citations
Nearly 100% knockout efficiency and over 86.67% integration efficiency were achieved in the described experimental cases with this novel pop-in/pop-out-based editing system, which provides a new gene-editing tool for synthetic biology in Pichia pastoris.
Guo-Wei Zhao, Liang-Cheng Jiao, Yun-Chong Li et al.· Microbiology Research· 0 citations
Agriculture has always been a cornerstone of human civilization, providing food, raw materials, and employment. However, with the global population projected to reach nearly 10 billion by 2050, the demand for food production is expected to increase substantially (Godfray et al., 2010). Traditional farming methods are i...
Zorawar Singh· Zenodo (CERN European Organi...· 0 citations
The emergence of CRISPR-Cas9 genome editing has now broadened the scope of precise modification of genes that play a role in biosynthesis of secondary metabolites in medicinal plants. Medicinal plants generate a variety of bioactive compounds, such as alkaloids, terpenoids, phenylpropanoids, and glucosinolates, and the...
Hira Aftab, Ahmed Shakeel, Shakir Ahmed Khan et al.· Journal of Biomolecules Path...· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
