Inherited mitochondrial cardiomyopathies arise from pathogenic variants that disrupt oxidative phosphorylation, mitochondrial DNA maintenance, cardiolipin biogenesis, or mitochondrial dynamics and quality control. Although the causative genes are diverse—mtDNA mutations, nuclear respiratory-chain and assembly factors,...
Findings place silkworm cryptochromes at a key interface between environmental sensing, circadian timing and seasonal developmental control, with potential implications for sericulture.
Daniel J. Brady, Federica Sandrelli· Frontiers in Physiology· 0 citations
It is argued that CRE function is not only an intrinsic property of DNA sequence alone but also emerges from a multidimensional context, including chromatin accessibility, histone modifications, three-dimensional genome topology, and cell type-specific regulatory landscapes, which promises to transform the ability to r...
Li-Bin Zhang, Maoteng Li· Journal of Integrative Plant...· 0 citations
This review provides a next-generation perspective on vermiremediation by integrating species-level physiology, gut microbiome functionality, molecular detoxification pathways, synthetic biology innovations, multi-omics insights, and artificial intelligence (AI)-driven modeling into a unified framework.
Inrikynti Mary Kharmawphlang, María Gómez-Brandón, Nazneen Hussain· Biodegradation· 0 citations
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A rapid nanopore sequencing pipeline is highlighted, which is named NanoCutSight, to quantify the percentage of indels at a specific genomic locus and to identify the types of modifications generated.
Danny Bergeron, Véronique Gaudreault, Maxime Duval et al.· bioRxiv· 0 citations
The present study represents the first application of base editing in barley plants, using the EIF4E gene as an example, and two newly generated alleles led to resistance upon BaMMV inoculation without adverse effects on yield, proving this approach promising to generate new material for resistance breeding.
R. Hoffie, A. Habekuss, D. Perović et al.· bioRxiv· 0 citations
By linking genomic variation with molecular regulation, cellular phenotypes and tissue organization, reproductive organoids represent promising preclinical platforms for understanding human infertility and may ultimately contribute to the development of precision reproductive medicine.
Paul Barreau, C. Djari, J. de Vos et al.· Genes· 0 citations
Curative SCD therapies are converging on the same challenge: establishing durable healthy hematopoiesis with acceptable toxicity, and progress will depend on graft quality, safer niche creation, patient-centred outcomes and equitable delivery.
Giula Mackina, Panicos Shangaris· Current opinion in hematolog...· 0 citations
This review delineates the recent advancements in discovery of CRISPR‑based genome editing tools, with a particular emphasis on delivery strategies across in vitro modeling, ex vivo cellular engineering, and in vivo clinical interventions.
Li Du, Xiao-Feng Hua, Qianquan Ma et al.· Molecular Medicine· 0 citations
Functional analysis of neuronal activity reveals delayed synaptic maturation in loss-of-function mutations and insights into how KIF1A mutations with distinct molecular-level impacts lead to significant downstream synaptic deficits in human neurons.
Jayne Aiken, Carris Borland, Nicolas Marotta et al.· Journal of Cell Biology· 0 citations
This study constructed a triple gene-edited and Urist-processed xenogeneic decalcified bone matrix system, offering an innovative gene-editing bone repair strategy to overcome immune rejection challenges in xenogeneic bone grafts and illuminates the therapeutic prospects of synergistically attenuating xenotransplantati...
Yuan-Hang Han, Yi-Fan Hu, Yu-Shen Lu et al.· Biomaterials· 0 citations
Zero-knowledge proofs can verify computing results without rerunning workloads or exposing sensitive data. Magnetar helps bring them into the mainstream with support for standard programming languages, major speed gains, and quantum-resistant security. The post Proof-based general-purpose computing with Magnetar appeared first on Microsoft Research.
