On-policy distillation (OPD) has recently been introduced as a promising paradigm for continual learning, where a student policy can be supervised at the token-level. Typically, OPD is performed using a single teacher per prompt rollout (or even per training run). However, this ignores a whole other axis of flexibility...
Stanley Wei, Jiin Woo, Kaan Ozkara et al.· 0 citations
Unlearning aims to remove selected knowledge from large language models to mitigate privacy and safety risks while preserving useful capabilities. For models that continue to be fine-tuned after release, this goal is insufficient: they must also resist relearning the deleted knowledge while preserving plasticity, the a...
Accurate medium- to long-range epidemic forecasting requires extrapolating high-dimensional, heterogeneous and nonstationary dynamics from partial observations. Yet hybrid models often leave implicit which observations inform which epidemic processes and how learned graph interactions modify system state. We introduce...
Despite a surge of empirical interest in the ``unreasonable effectiveness''of drastic data pruning for AI systems, a unified theoretical understanding of this phenomenon remains elusive. In this work, we provide a precise high-dimensional theory of learning under data pruning via weighted empirical risk minimization (E...
Elvis Dohmatob· 0 citations
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Protein foundation models increasingly support the generation of novel biological sequences, yet their reliance on large public datasets creates opportunities for adversarial manipulation of the material they learn from and retrieve. We investigate two data-only poisoning attacks against protein design systems, targeti...
Charalampos Koilakos, K. Provatas, Michail Patsakis et al.· 0 citations
Instruction-following language models can comply with requests that conflict with intended behaviors and safety alignment. We introduce a training-free weight-editing approach for reducing compliance with targeted undesirable instructions. Our method needs only forward passes on a small set of prompt pairs per target b...
Ali Ebrahimpour-Boroojeny, Xiao-Cong Yang, Samuel Schapiro et al.· 0 citations
Faulty sensor readings can distort estimates of fuel use and carbon dioxide emissions from diesel engines. We evaluate two procedures that use relationships learned from healthy measurements to diagnose faults and guide fuel correction. The diagnosis procedure tests whether replacing a suspected faulty reading with an...
Predicting live birth before fresh embryo transfer could support shared decision-making in IVF/ICSI, but routine clinical data are small, heterogeneous, and contain pathway-dependent variables prone to outcome leakage. We aimed to construct a curated single-centre IVF/ICSI dataset and develop a prediction model suited...
Abdul Raheem Shahzad, Jin-Xin Chen, Ming Zhang et al.· 0 citations
Few-step generative models produce high-quality samples in one or a few evaluations. However, steering them toward desired properties remains difficult, especially when only black-box reward evaluations are available. While one could apply approaches developed for iterative diffusion and flow-based models, such as dire...
Woocheol Shin, Taeyoung Yun, Jiwon Sung et al.· 0 citations
Post-hoc image explanations usually show where a model looks using spatial heatmaps or indicate which channels matter using global channel scores. These separate views are limiting for multispectral data because channel relevance is often spatially localized and physically meaningful. We introduce Spectral-Spatial Inte...
Haotian Ma, Ruqi Yang, Philip Townsend· 0 citations
Score-based diffusion methods usually perturb data with Brownian Gaussian noise, corresponding to a light-tailed forward stochastic differential equation (SDE). For market time series this SDE can be a poor abstraction: limit order book (LOB) order flow is heavy-tailed, bursty, and occasionally jump-like. We study STOC...
Learned dynamical models can accurately predict trajectories while producing unreliable sensitivities when differentiated or transposed, limiting their use in inverse problems and scientific decision-making. Classical adjoints provide exact local derivatives, but a single adjoint cannot represent the nonlinear response...
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
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