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1,585 papers
A novel committor learning framework grounded in the AlphaFold 3 paradigm is proposed that elucidates how ligand substituents regulate the ratio between distinct binding pathways, offering new perspectives for structure-based drug design.
MemDefrag, a training-free and model-agnostic framework that uses a middle-layer tracing signal to conduct memory defragmentation (rank, reorder, and filter memories), and applies an informativeness-guided proportional forgetting mechanism once capacity is exceeded, is proposed.
This work uses a full $2^3$ factorial design to decompose three recurring interventions in formalization pipelines: parametric expert drafting, Mathlib/context search, and Lean elaboration feedback, suggesting that formal validity, proof-oriented Lean competence, and faithful statement generation should be reported separately.
EmoTrace, a multi-turn dialogue corpus generation framework centered on modeling seekers' emotional trajectories, is proposed, which outperforms existing approaches in terms of emotional richness and empathy quality.
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Gaokerena, a novel family of compact Persian medical language models optimized for deployment on consumer grade hardware, and Gaokerena-R, a novel family of compact Persian medical language models optimized for deployment on consumer grade hardware, are presented.
A large-scale empirical study across a diverse set of embedding models and 275+ languages spanning three parallel datasets, exposing persistent gaps in cross-lingual semantic representation that track language prevalence in training resources and subword tokenization.
LookBack, a training-free LVLM response scoring method that augments token likelihood with visual lookback score, a lightweight measure of how strongly each response token refers to image tokens, consistently improves Best-of-$N$ selection over existing baselines with negligible additional overhead.
This paper introduces Caduceus, a family of MoE-enhanced foundation models built with a hierarchical pre-training paradigm to jointly integrate biological and natural language, and incorporates a multi-task instruction tuning phase, enabling robust protein parsing and natural language question answering.
The null token is turned into a diagnostic lens on hallucination and motivate evaluating abstention methods by both suppression and deletion costs, rather than by hallucination reduction alone.
Scaling transformer language models creates an inherent tension between expressivity and memory efficiency. While unique weights across layers preserve functional specialization---from input-grounding to abstract refinement---they incur a substantial memory footprint. Conversely, standard depth-sharing enforces uniform transformations that collapse representational diversity and degrade modeling quality. We introduce Gated Recurrent Transformer, a recurrent depth transformer where fixed-depth prelude and coda blocks bracket a single shared core iterated R times. Inspired by gated recurrent neural networks, we employ a lightweight projection and an elementwise update gate---conditioned on the hidden state, the fixed prelude output, and noise resampled at every step---to modulate the recurrent update. This allows the model to specialize the input to the same few layers across recurrences, rather than requiring many unique layers to achieve functional diversity. Under an isoFLOPS constraint, a 3-layer Gated Recurrent Transformer matches the accuracy of a 12-layer GPT-2 Small baseline with similar training and inference FLOPs, and leads MoR and heavy-tail depth sampling in all nine scale-by-budget cells; at medium and large scale it approaches dense quality at the standard token budget and overtakes it at medium scale once that budget is doubled. Under an isoPARAMS constraint, deeper recurrence achieves a 2.76 validation loss versus 2.84 for a non-recurrent counterpart at matched parameter and data budget. Our results demonstrate that adaptive depth reuse is a principled strategy for trading parameters for quality: at large scale, 63% fewer parameters and 59% less peak decoding memory for a 10% increase in compiled generation latency.
Post-training alignment is often shallow, eroding under fine-tuning. It remains untested as to whether constitutional midtraining interventions can produce durable alignment when cleanly isolated from post-training. We build a 394M-token constitutional corpus from Anthropic's Constitution and apply constitutional midtraining at 120B scale, where principled, values-based content is inserted into midtraining. A 2x2 design (curriculum ordering x deliberative reasoning) was used to produce four constitutionally midtrained conditions, plus a control, which were evaluated on self-generated and established benchmarks including alignment under pressure, value conflict resolution, blackmail, and emergent misalignment. All models were evaluated across three stages: post-midtraining, post-SFT, and post-benign fine-tuning. Constitutionally midtrained models outperformed the control on alignment generalization and durability, notably on blackmail: SFT instilled a blackmail propensity in all models, but constitutional midtraining blunted it, with the advantage surviving benign fine-tuning (-17.5pp). This durability did not extend to settings that required active resistance to in-context pressure or conflict, where the advantage attenuates after SFT. The presence of constitutional content at midtraining also mattered more than its structure, and constitutional midtraining incurred no capability cost, on average, at any stage (MMLU, ARC-Easy, piqa, GSM8K). A modest amount of constitutional content at midtraining could therefore yield broad, persistent alignment gains, offering a cheap, complementary addition to SFT-centered pipelines. Code, data, and models are available.
Reinforcement learning (RL) post-training for large language models (LLMs) follows a efficient paradigm of "rollout then update", which inevitably results in off-policy training data. To resolve this, Importance sampling (IS) is proposed, while the token-level ratios compound over long sequences, causing severe variance exploded. A natural idea is "transferring" these off-policy token into on-policy token, so that the importance scores for correction are unnecessary. Following this idea, we propose Selective Importance Sampling (SIS), which is inspired by rejection sampling. Concretely, SIS implements by viewing off-policy model as proposal distribution, and implement a token-level rejection test: accepted tokens are viewed as on-policy, so that receive unit importance score, while rejected tokens retain the standard IS correction. Our proposed SIS is theoretically proved reducing the gap between token-level and sequence-level off-policy gradient estimators. The SIS acts as a plug-in that only modifies the importance ratio in the policy loss, adding negligible wall-clock overhead, and can be combine with a vast vary of RL post-training algorithms. Experiments on dense and MoE LLMs across math and agent benchmarks show that SIS consistently improves all objectives, while providing substantially stronger robustness under off-policy data.
A new method, called CW-Net, translates the reasoning process of an autonomous vehicle’s AI system into understandable concepts that explain its behavior.
With millions of users across the world, Julia has been used to conduct cutting-edge research and to design new drugs, jet engines, heat pumps, and more.
We’re on a journey to advance and democratize artificial intelligence through open source and open science.
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
Algorithms & Theory
New MIT research could lead to better materials for a fossil-fuel-free process for making the chemical that's essential to fertilizer and other products.
