Bio The silent flame of obesity: inflammation and risk for diabetes

Emerging evidence of trained immunity and inflammatory programming in atherosclerotic cardiovascular disease.

Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide despite major advances in risk factor attenuation and lipid-lowering therapies. Inflammation is a central driver of atherosclerosis, contributing to disease initiation, progression, and excess cardiovascular risk. T...

Bidirectional crosstalk between obesity and the lymphatic system: a novel pathway in obesity pathogenesis and treatment.

Obesity and thyroid cancer: mechanisms and clinical implications

The global rise in obesity has paralleled the increasing incidence of thyroid cancer, suggesting a potential pathophysiological link. This review comprehensively examines the epidemiological evidence linking obesity to thyroid cancer risk and progression, and elucidates the underlying biological mechanisms. Adipose tis...

Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications

ABSTRACT Type 1 diabetes is defined by immune‐mediated beta‐cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insuli...

Free Fatty Acids and Sarcopenia Risk in Type 2 Diabetes: Insights From SHAP Analysis

Sarcopenia is a prevalent and disabling complication of Type 2 diabetes mellitus (T2DM), which significantly elevates the risks of falls, fractures, institutionalization, and all‐cause mortality. Lipotoxicity mediated by circulating free fatty acids (FFA) is crucial in the pathogenesis of diabetes‐related sarcopenia, b...

The Application of Anti-inflammatory Diet Patterns in Weight Control of Obese Population: Mechanism and Clinical Manifestations

Obesity is now a serious public health problem worldwide, which is closely related to chronic low-degree inflammation and metabolic disorders. Over recent decades, people have been paying increasing attention to the anti-inflammatory diet in obesity management. This review summarizes the potential mechanism and clinica...