Open access
Association Between PM2.5 Components and Cerebral Hypoperfusion: A Mediation Role of Inflammatory Biomarkers
Xing-Yan Xu
Xinyue Lu
Nan Wang
Liu-Yan Zheng
Jian-Hui Guo
Tong-Jin Xu
Yi-Ming Guo
Hao Li
Yi Yang
Le Yang
Medicine
Abstract
Cerebral hypoperfusion, an acute manifestation of intracranial arterial stenosis (ICAS), is particularly concerning among older East Asian adults given its high prevalence. Systemic inflammation triggered by PM2.5 exposure has been linked to cerebrovascular diseases, yet evidence on its specific components of hypoperfusion in this vulnerable group remains limited. We explore associations between PM2.5 and its components exposure with cerebral hypoperfusion, and assess mediation by inflammatory indicators.