In Vitro Anti-Inflammatory Evaluation, Gene Expression, HR-LC–MS Profiling, and in silico Molecular Docking of Active Fraction from Rauvolfia densiflora Benth. ex Hook.f. (Apocynaceae)
The 28th fraction of the methanolic stem extract of R. densiflora demonstrated significant in vitro anti-inflammatory activity, supported by both biochemical assays and molecular analyses, suggesting the fraction has potential as a source of anti-inflammatory drug leads.
Inflammation is a complex biological response associated with the overproduction of reactive oxygen species (ROS) and the release of inflammatory mediators. The development of anti-inflammatory agents from natural products with antioxidant properties can improve their safety and efficacy. This study aimed to characte...
Devyana Dyah Wulandari, Yenni Pintauli Pasaribu, Arif Fadlan et al.· EPJ Web of Conferences· 0 citations
Preliminary scientific evidence for utilization of G. diversifolia as traditional medicine for treating rheumatism is provided and a foundation for future pharmacological investigations of this underexplored medicinal species is established.
Sumiran Dewan, Sona Limboo, D. R. Chhetri et al.· In Silico Pharmacology· 0 citations
The specific molecular interactions suggest that the bio-functional efficacy of L. canescens might be driven by its phenolic-rich chemical composition and potential multi-target modulation of apoptotic and survival pathways.
Muhammed Gungoren· Scientific Reports· 0 citations
The current study was carried out to determine the in vitro antioxidant and antidiabetic potential and phytochemical profiling of crude extract obtained from the cone of Magnolia zotictla, and then to integrate it with computational chemistry. Phytochemical profiling was determined via HPLC and GC–MS analysis. In HPLC...
M. Zahoor, U. Shah, Marwa Bibi et al.· Chemistry and Biodiversity· 0 citations
Background: The caper plant (Capparis spinosa) is a medicinal plant known for various pharmacological properties that largely reflect its rich chemical composition. This research sought to determine the chemical components of the plant's ethanolic extract by gas chromatography-mass spectrometry (GC-MS) and to assess th...
M. A. Ibraheem· International Journal of Bio...· 0 citations
This study integrated HPLC-Q Exactive Plus MS/MS analysis, network pharmacology, molecular docking, and in vitro assays to investigate the anti-liver cancer mechanisms of flavonoid components from Rosa roxburghii Tratt. (RRT) ethanol extract. A total of 52 flavonoids were identified, including 15 active compounds assoc...
M. Zeng, Hui-Fang Chai, Yong-Jia Shu et al.· Natural Product Research· 0 citations
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