The existing mechanistic knowledge about the PTBP1 functions during viral infection is described and the possibility of PTBP1 being used as a host-directed antiviral drug target despite the hurdles in doing so considering its multifunctionality as an essential cellular RNA-binding protein is explored.
It is demonstrated that human La autoantigen (La protein) specifically binds to GCAC sequence near the initiator AUG within the 5’UTR of SARS-CoV-2 RNA promoting viral non-structural protein synthesis by cap independent translation, while suppressing replication early in infection.
Risabh Sahu, Harsha Raheja, S. N. Gagan Gaurav et al.· bioRxiv· 0 citations
Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne pathogen that causes substantial morbidity and high case fatality in severe cases, representing a major public health concern in East Asia. Although protein-mediated mechanisms of SFTSV replication and immune evasion have been extensive...
Aofan Wang, Jiale Li, Lin Chen et al.· Virologica Sinica· 0 citations
Using SARS-CoV-2 infection models, it is shown that viral replication is associated with increased cellular m7G signal, supporting the relevance of this pathway during infection and suggesting that NSP14-induced m7G modification may contribute to the remodeling of host gene expression during coronavirus infection.
ABSTRACT Circular RNAs (circRNAs) are covalently closed RNA molecules with increasingly recognized roles in post-transcriptional gene regulation, immune signalling, and host–pathogen interactions. Although circRNAs have been characterized across diverse biological contexts, their roles in viral infection, particularly...
Gabriela Berger, Y. G. Chen· RNA Biology· 0 citations
The orthoflavivirus capsid (C) protein is a multifunctional protein that plays essential roles throughout the viral life cycle. Besides viral RNA encapsidation for nucleocapsid assembly, it associates with lipid droplets, interacts with host proteins, and translocates to the nucleus, although its nuclear functions are...
N. C. Mebus-Antunes, Dayane Henriques, A. D. Da Poian· Molecules· 0 citations
Filoviruses, such as Ebola virus (EBOV), are highly pathogenic non-segmented negative-sense RNA viruses (nsNSVs) with limited therapeutic options. Filovirus RNA structures remain largely untapped due to the enhanced biosafety requirements for handling infectious virus. Here, we present the first in-cell secondary struc...
Michelle Luo, J. Olejnik, K. Meier et al.· bioRxiv· 0 citations
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