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LINE-1 transposon derepression and epigenetic remodeling in Retinoblastoma

Aman Verma Sugam Kumar Patel Akhil Varshney Pratyashaa Paul R. Sachdeva V. Sangwan Sima Das Bhavana Tiwari Anil Tiwari
Jul 2026 · bioRxiv · 0 citations · 45 references
Biology

TL;DR

It is shown that retinoblastoma is associated with LINE-1 promoter hypomethylation, increased LINE-1 transcript expression, ORF1p accumulation, and preferential activation of selected LINE-1 loci, which is associated with altered expression of oncogenic signalling pathways and host factors involved in transposable element repression.

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