AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
A framework for understanding microbial contributions to aging is offered and potential directions for future research aimed at extending healthspan in higher organisms are highlighted.
The shared longevity genes identified in this work offer potential targets to promote healthy aging and decrease age-onset disease.
Examination of evidence surrounding mitochondrial dysfunction, oxidative stress, and gut microbiome dysbiosis across humans, mice, and fruit flies under spaceflight and corresponding terrestrial control conditions finds that biomarker genes most associated with mutation accumulation and antagonistic pleiotropy appear t...
Even though there is a general agreement on the heritability of longevity in humans, the complex network of genetic and non-genetic factors affecting our lifespan is far from being fully elucidated. In this context, simple model organisms can still contribute to understanding the fundamental mechanisms involved in long...
Abstract Humans and their associated microbes form a multifaceted ecosystem. Gaining mechanistic insight into this system necessitates reductionist models integrating ecological and immunological dimensions. Over the past decade, the gnotobiotic Oligo-Mouse-Microbiota (OMM12) mouse line has exemplified this approach, p...
Abstract Disruption of protein homoeostasis, or proteostasis, is a hallmark of protein conformational diseases (PCDs), including Alzheimer's and Parkinson's disease. These disorders are characterized by progressive protein aggregation and cellular dysfunction, yet no effective therapies exist. Emerging evidence indicat...
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