Whole transcriptome analysis reveals ELK3 as a key driver of metastasis through regulation of 3D migration and stemness in triple-negative breast cancer cells
A novel EFO2/USF1/SLC2A1 signaling axis that modulates glycolytic metabolism and CD8⁺T cell cytotoxicity is identified, positioning EFO2 as a promising therapeutic target for TNBC treatment.
Lin Jia, Liru Li, Junning Peng et al.· Biochemical Pharmacology· 0 citations
Elevated TPD52 expression was associated with longer overall survival in specific subgroups, including the basal-like subtype, invasive lobular carcinoma, and N0/N1 stages, and a random forest-based diagnostic model demonstrated high accuracy across multiple datasets.
J. Yu, Z. Zhu, R. Deng et al.· medRxiv· 0 citations
This study reveals post-transcriptional regulation of METTL3 by miR-338-5p by confirming a functional miR-338-5p/METTL3/m6A axis in TNBC and targeting this distinct regulatory axis represents a promising therapeutic strategy for TNBC.
Wen-Jia Chen, Ya Xu, Yang-Zheng Lan et al.· Clinical and Translational O...· 0 citations
Investigation of the role of frizzled class receptor 4 in OS progression found that it is highly expressed in OS and is associated with poor prognosis, and miR-424-5p can regulate these tumor-promoting effects by targeting FZD4.
Jing-Jin Ma, Yi Yang, Tong Liu et al.· Cancers· 0 citations
It is discovered that METTL3 depletion uniquely triggers a severe halt in cell division in HCC1143 cells, while universally disrupting actin-associated cell motility across different backgrounds, demonstrating that METTL3 acts as a context-dependent modulator of cell fate rather than a monolithic driver.
Buket Sağlam-Şen, Azime Akçaöz-Alasar, Ahmet Batuhan Dondurur et al.· bioRxiv· 0 citations
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