2026· Methods in molecular biology· Vol 3056, pp.
165-195
· 0 citations
Medicine
TL;DR
This chapter explores the biomedical significance of ceRNAs, highlighting their role in modulating gene expression and their potential implications in disease, and summarizes available tools, resources, and practical examples for studying lncRNA-miRNA interactions to aid researchers in navigating this sophisticated regulatory network.
This chapter provides an overview of numerous computational approaches developed to reconstruct circRNA-miRNA-mRNA networks, ranging from specific circRNA-oriented applications to sequencing-based tools, each with distinct strengths and limitations.
S. Avesani, L. Cascione, R. Giugno· Methods in molecular biology· 0 citations
It is proposed that the upregulated lncRNA ENSG00000265613 may enhance malignancy by stabilizing the RNA target ENSG00000582008 in luminal A breast cancer, particularly given its established role in oncogenesis.
C. Guda, Sankarasubramanian Jagadesan, Avinash M. Veerappa· Methods in molecular biology· 0 citations
Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, circular RNAs, tRNA-derived fragments, PIWI-interacting RNAs, and small nucleolar RNAs, have been identified as crucial regulators of gene expression and key drivers of cancer progression. Natural products, owing to their structural diversity and mult...
