Artificial intelligence (AI) and machine learning (ML) have emerged as powerful tools for metabolic engineering by enabling pathway prediction, metabolic flux optimization, enzyme engineering, and identification of bottlenecks throughout terpenoid biosynthesis.
This chapter focuses on research progress in metabolic engineering of BT production, which mainly includes design of BT biosynthetic pathways for expression in bacterial and yeast cell factories, current metabolic engineering and process optimization strategies to optimize BT production, and utilizing lignocellulosic b...
Weibin Wang, Mengrui Tao, Kai Li et al.· Advances in Biochemical Engi...· 0 citations
This review systematically summarize recent progress in the metabolic engineering of Candida species as microbial cell factories, with particular emphasis on expanding genetic toolkits, utilizting renewable and non-conventional carbon sources, and biosynthesizing high-value compounds.
This review provides the current state of PHAs production from wild yeast strains and the various approaches that have been used to improve yield, and discusses the performance, challenges, and limitations of various synthetic biology and metabolic engineering strategies in yeast strains for PHAs production.
K. Mohanrasu, R. Selvakumar, I. Grainge et al.· International Journal of Bio...· 0 citations
The convergence of fungal systems biology with the principles of circular bioeconomy is illustrated and the technological, economic, and regulatory bottlenecks which need to be overcome are pointed out to fully realise the potential of fungi as the biofactories of the future for the sustainable production of energy and...
B. Thakur, Sukhminderjit Kaur, Ranjan Singh et al.· Journal of Pure and Applied...· 0 citations
This review critically discusses various cyanobacterial species and strains used for the production of different terpenes, which are in high demand at present and addresses key challenges that must be considered for sustainable terpene biosynthesis, including terpene synthase enzyme expression, rate-limiting steps in u...
Aakash Kamalesan, K. Kumar, Bharathi Nathan et al.· Archives of Microbiology· 0 citations
Terpenoids are a class of natural products widely distributed in living organisms, with isoprene as their fundamental structural unit. However, traditional plant extraction and chemical synthesis methods are often limited by low product purity, difficult separation, and complex synthetic steps, making it challenging to...
