Adipose‐derived stromal vascular fraction (SVF)‐gel has an autologous origin and favorable immunocompatibility and exhibits favorable safety and efficacy in facilitating cartilage regeneration and repair.
Abstract
Osteoarthritis (OA), a prevalent degenerative joint disorder, is suboptimally managed by existing treatments owing to adverse effects, limited therapeutic efficacy, and the inability to achieve genuine cartilage repair. Adipose‐derived stromal vascular fraction (SVF)‐gel, which is abundant in stem cells and bioactive factors, has an autologous origin and favorable immunocompatibility and exhibits favorable safety and efficacy in facilitating cartilage regeneration and repair. Building upon prior research, this review discusses the clinical efficacy and potential of SVF‐gel, while also recognizing challenges such as the standardization of preparation procedures and dosage optimization. Future research ought to concentrate on integrating advanced technologies, including gene editing, artificial intelligence (AI), and nanomaterials, to drive its development towards more precise and personalized therapeutic approaches.
Osteoarthritis (OA) is a common degenerative joint disease characterized by pain, stiffness, progressive cartilage loss, and reduced mobility. Current treatments primarily aim to relieve symptoms rather than restore damaged cartilage, and durable regeneration of native hyaline cartilage remains a major clinical challen...
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Emerging clinical evidence across cell-based strategies, biomaterial- and scaffold-assisted repair, biologics, and combination approaches is assessed, emphasizing integrated, multimodal approaches and standardized outcome measures as essential for achieving durable cartilage repair and true disease modification.
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Biologic and regenerative interventions represent promising avenues for advancing cartilage repair and improving clinical outcomes in patients with osteoarthritis, and current evidence indicates that these therapies exert their effects through modulation of inflammatory pathways, enhancement of extracellular matrix syn...
Hai-Yuan Yue, Ahmad Alhaskawi, S. Ezzi et al.· Frontiers in Pharmacology· 0 citations
This review provides an analysis of OA abnormalities, including biophysical, cellular, and biochemical aspects, and the design principles of cell-based biomaterials based on these abnormalities, and summarizes various varieties of cell-based biomaterials and the recent advances of their applications in OA treatment.
Osteoarthritis (OA), a prevalent chronic degenerative joint disorder, affects hundreds of millions of people worldwide and has become a leading cause of joint pain and functional impairment in middle-aged and elderly populations. It not only severely compromises patients’ quality of life but also imposes a significant...
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Chronic tendinopathy is a debilitating tendon overuse disorder characterized by localized tenderness, swelling, and pain, significantly impairing physical function. It is particularly common among the overuse and aging populations. Traditional treatment options, including conservative therapies and surgical interventio...
Haining Liu, P. P. Lui· Stem cell research & therape...· 0 citations
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