TL;DR
The key challenges to GBM therapy are summarized and folate-decorated nanotheranostics, via tailored chemistry and increased tumoral contact, constitute a potential option for GBM precision therapy.
Glioblastoma (GBM) remains one of the most lethal and intractable central nervous system malignancies, characterized by aggressive cellular proliferation, profound hypoxia, and an immunosuppressive microenvironment. The primary pharmacokinetic obstacle for systemic interventions is the blood–brain barrier (BBB), which...
Glioblastoma (GB) is a highly aggressive tumor that demonstrates significant treatment resistance due to the blood-brain barrier (BBB) and resistance mechanisms of the tumor. Nanoparticle- based drug delivery systems (NDDS) can enhance drug bioavailability, enable targeted delivery, and provide controlled release. Thes...
The combined LF–nanocarrier approach represents a rational and innovative strategy for improving treatment outcomes in glioblastoma multiforme and enhances therapeutic efficacy, stability, and safety of anticancer agents.
This review critically examines advanced surface functionalization strategies, including chemical functionalization (amine, thiol, carboxyl groups), ligand conjugation (antibodies, aptamers, peptides), and polymeric coatings that enhance BBB penetration, facilitate tumor-specific targeting, and enable stimuli-responsiv...
This comprehensive review on Nanotechnology focuses on the entire spectrum of ovarian cancer management and recent advances in physicochemical properties, PK/BD, diagnostic biosensors, treatment modalities to reverse MDR, immunomodulation and personalized nanomedicine are summarized.
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