Alzheimer disease neuropathologic change (ADNC) does not fully explain clinical severity, suggesting important contributions from coexisting pathologies, and clinical severity therefore cannot be inferred from ADNC alone.
Bomarker-confirmed AD comprised internally reproducible atrophy trajectories with distinct cognitive, vascular, and molecular profiles and may complement fluid biomarkers and conventional volumetry for patient stratification and prognosis.
Chen-Hui Mao, Yu-Yue Qiu, Bo Li et al.· NeuroImage· 0 citations
OBJECTIVE
Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease (AD), with significant pathological overlap between the two conditions. However, the impact of Alzheimer's co-pathology on basal forebrain (BF) atrophy and its relationship with neurodegeneration and...
Daniele Urso, Thomas Giannelli, B. Tafuri et al.· Annals of Neurology· 0 citations
Recent advances in structural MRI, diffusion tensor imaging, magnetic resonance spectroscopy, quantitative susceptibility mapping, arterial spin labeling, and functional MRI for evaluating hippocampal and medial temporal lobe abnormalities in AD are summarized.
Yao Wang, Zhengsheng Gu, Hailing Zhang et al.· Japanese Journal of Radiolog...· 0 citations
Distinct patterns of cerebral perfusion-cognition relationships characterize AD and DLB, reflecting differential regional vulnerabilities underlying cognitive decline, which may contribute to improved understanding of the pathophysiology underlying cognitive decline and support disease monitoring.
Yume Koizumi, Yoshikazu Nakano, Mitsuyoshi Tamura et al.· Journal of Alzheimer's Disea...· 0 citations
PD-MCI was characterized by distributed hippocampal diffusivity alterations despite the absence of detectable volumetric differences, and subfield-specific diffusion measures may provide complementary information on cognition-related hippocampal involvement beyond conventional volumetry.
Yu-Mei Chen, Lu Peng, Qing Hu et al.· Frontiers in Aging Neuroscie...· 0 citations
A practical multi-axis framework comprising clinical phenotype, AD biological context (AD pathology plus co-pathologies and molecular modifiers), network topography (regional patterns) and tempo (rate of clinical and biomarker progression) is proposed to reduce diagnostic mismatches, make cohorts more comparable and su...
L. Grinberg, M. Murray· Nature Reviews Neurology· 0 citations
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