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The PSD-95 interactome of hippocampal synapses potentiated in response to an in vivo learning task

A. Jacob M. Di Caprio I. Arisi F. Gobbo F. Latini Andrea Faraone L. Zentilin I. Heinze Silvia Marinelli Alessandro Ori Marco Mainardi A. Cattaneo
Sep 2026 · bioRxiv · 0 citations
Biology

TL;DR

SynActive-PSD95-FLAG, a genetically encoded probe consisting of FLAG-tagged PSD- 95 endowed with activity-dependent local translation and expression enrichment at potentiating dendritic spines, provides new insight into the molecular substrates of hippocampal learning and a novel tool to study the proteome of potentiated synapses.

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