TL;DR
Investigating the anti-obesity properties of rabbit meat extract and determining its bioactive peptides found peptide-3(GEAGPQGARG) exhibited the most potent bioactivity, characterized by the upregulation of thermogenic genes and the concurrent downregulation of adipogenic markers within adipocytes.
Metabolic dysfunction–associated steatotic liver disease (MASLD) is closely linked to obesity, insulin resistance, and endocrine dysregulation. Although calorie restriction is widely used for metabolic control, it is often accompanied by unintended skeletal muscle loss, which may negatively affect long-term metab...
Findings identify skeletal muscle as an early target of fat-induced metabolic dysfunction and support further investigation of OEA as a promising pharmacological strategy to intercept obesity-associated metabolic deterioration before overt obesity develops.
Browning is a process wherein white adipocytes differentiate into brown-like adipocytes. This process is one of the key signatures of overcoming obesity. Notably, several functional foods and dietary supplements can induce browning in human body. One such naturally occurring compound is dehydrozingerone (DHZ), which...
HFD feeding caused insulin resistance and impaired iBAT mitochondrial functions and thermogenic activity, due to lipid accumulation, and chronic cold exposure improved insulin sensitivity and restored iBAT oxidative metabolism and mitochondrial functions.
Background Obesity and related metabolic complications are associated with adipose tissue (AT) dysfunction, which contributes to metabolic inflexibility. However, the underlying mechanisms remain unclear. Our previous studies demonstrated that a high-fat diet (HFD) induces weight gain, increased fat weight, as well as...
Overall, adipose tissue browning represents a promising component of a systems-based approach to MASLD and should focus on integrating mechanistic insights with clinical investigation to clarify its therapeutic potential and to identify strategies that enable durable and patient-specific metabolic benefits.
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
