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Peroneutone A, a new highly oxygenated diterpenoid with diverse biological activities from Peroneutypa scoparia

· Records of Natural Products · Vol 21 · 0 citations

TL;DR

Compounds 1–4 showed antifungal and anti-inflammatory activities, and 1 exhibited the strongest inhibition against Candida albicans together with selective cytotoxicity toward A549 cells, expanding the chemical and biological diversity of pimarane diterpenoids from P. scoparia.

Abstract

A chemical investigation of the endophytic fungus Peroneutypa scoparia RJHH-3 led to the isolation of a new highly oxygenated pimarane diterpenoid, peroneutone A (1), together with three known analogues, scopararane C (2), libertellenone A (3), and 9α-hydroxyisopimara-8(14),15-dien-7-one (4). The structure of 1 was established by HRESIMS and extensive NMR analyses, while its stereochemistry was determined by NOESY, NMR calculations, DP4+ analysis, and ECD calculations. Compounds 1–4 showed antifungal and anti-inflammatory activities, and 1 exhibited the strongest inhibition against Candida albicans (MIC = 0.6 μM) together with selective cytotoxicity toward A549 cells (IC50 = 6.9 μM). These findings expand the chemical and biological diversity of pimarane diterpenoids from P. scoparia.

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