Bullatine A Attenuates Proliferation in Breast Cancer Cells by Apoptosis via PI3K/AKT/mTOR Signaling Pathway in Vitro and in Silico Analysis and Pharmacological Analysis

Sophocarpine Inhibits Proliferation and Triggers Apoptosis in Breast Cancer Cells by Modulating the miR-21/PTEN/AKT and ERK1/2 Signaling Networks

Background: Sophocarpine (SC), a tetracyclic quinolizidine alkaloid, has shown antitumor potential, yet its activity and underlying mechanisms in breast cancer remain unexplored. This study aimed to investigate the anticancer effects of SC and the molecular mechanism, focusing on the involvement of microRNA-21 (miR-21)...

Neutrophil extracellular traps induce chemoresistance in human breast cancer cells through the PI3K/AKT/NF-κB pathway

Findings identify heat-labile, NET-associated components as mediators of breast cancer chemoresistance and support targeting NETs or their downstream signaling pathways to improve chemotherapy response.

PDK1/AKT signaling is involved in the anti-tumor effect of gramine and cisplatin chemoresistance in ovarian cancer cells

Ovarian cancer (OC) remains one of the most lethal gynecologic malignancies, with limited therapeutic options and poor long-term prognosis. Gramine, an indole alkaloid predominantly derived from the rhizomes of Arundo donax L., has demonstrated antitumor activity in various cancer types; however, its effects and mechan...

Saikosaponin A Induces Apoptosis in HCT116 Colorectal Cancer Cells via ROS-Mediated ER Stress and p38/JNK MAPK Pathway Activation: in Vitro and in Vivo Evidence

Colorectal cancer (CRC) is the third most prevalent cancer globally, with limited effective treatment options and significant chemotherapy resistance. Saikosaponin A (SSA), a triterpenoid saponin from Radix Bupleuri, exhibits anti-inflammatory and antitumor properties, but its mechanism of action in CRC remains und...

Robinin modulates TIMP-1/FAK/PI3K/Akt/mTOR-related signaling and induces oxidative stress-associated apoptotic responses in KB cells: in vitro and in silico evidence

Combined EGCG and miR-27a-3p Inhibition Attenuates Oncogenic Progression in MDA-MB-231 Triple-Negative Breast Cancer Cells

Triple-negative breast cancer (TNBC) is widely considered as one of the most challenging and aggressive forms of breast cancer with poor prognosis and limited treatment options. TNBC progression is associated with aberrant dysregulation of microRNAs (miRNAs) and oncogenic pathways like PI3K/AKT, which promote cell prol...