TL;DR
Insulin affects the viability of Luminal A breast cancer T-47D cells exposed to doxorubicin, indicating reduced cellular sensitivity to the cytotoxic effects of doxorubicin.
Breast cancer is one of the most common cancers worldwide, with a high incidence rate. Doxorubicin is a chemotherapeutic agent used in breast cancer management. Nevertheless, chemoresistance remains a major challenge in breast cancer chemotherapy. Insulin contributes to chemoresistance through its mitogenic and prosurv...
Breast cancer is the most common type of cancer characterized by uncontrolled growth of cells in breast tissue, constituting the most prevalent cancer in females worldwide. Standard treatments, including surgery, radiation, chemotherapy, and hormonal therapy, often exhibit elevated recurrence rates and considerable...
Triple-negative breast cancer is an aggressive subtype of breast cancer characterised by the absence of oestrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, a phenotype that severely limits targeted treatment options and is associated with poor clinical outcomes. Curcumin,...
Background: Breast cancer is the most diagnosed cancer among women worldwide and a leading cause of cancer-related mortality. It arises from the uncontrolled growth of cells in the breast tissue, most often in the ducts or lobules. Major risk factors include genetic predisposition, hormonal influences, increasing age,...
Objective: The purpose of this work was to analyze the effects of nanogenistein on the proliferation and metastasis of MCF-7 human breast most cancers cells, as well as to understand the underlying molecular mechanisms. Method: The MCF-7 human breast most cancers mobile panel was supplemented with 10% foetal bovine ser...
Triple negative breast cancer (TNBC) is the most fatal subtype of breast cancer. Cytotoxic chemotherapy and immune therapy remain the only available therapeutic strategies for treatment, but unfortunately, patients frequently develop drug-resistance. Drug resistance towards chemotherapeutic agents is a major obstacle f...
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