TL;DR
The review highlights the need for greater exploration of natural resources and redesigning of antibiotic development strategies to break free the stagnation that has been dominating the field of AMR for decades.
Advances in genomics, bioinformatics, and analytical chemistry have, in recent years, combined to show that there is still significant chemical diversity to be explored in microbes, providing an opportunity to revisit natural products for antibiotic discovery.
Artificial intelligence has moved convincingly beyond proof-of-concept in AMR diagnostics and discovery, but its path to the clinic now depends less on further algorithmic refinement than on prospective validation, equitable data representation, and interpretability standards that clinicians can reasonably trust.
Antibiotic resistance poses a threat to decades of clinical improvement and modern medicine, as antibiotics serve as the backbone of modern medicine, driven by a fundamental evolutionary mismatch: static antibiotics cannot outpace the rapidly adapting bacterial genome. Also, the development pipeline is stalled; antibio...
Artificial intelligence (AI) is reshaping modern drug discovery by enabling data-driven exploration of chemical space, predictive modeling of molecular interactions, and multi-objective optimization of therapeutic candidates. These capabilities are particularly important in addressing antimicrobial resistance, where co...
Antimicrobial resistance has intensified the need for new chemical matter and new mechanisms of action, yet antibacterial discovery remains unusually vulnerable to attrition between a convincing molecular hypothesis and clinically relevant whole-cell activity. This critical narrative review evaluates target-based and p...
Antimicrobial resistance is now among the most pressing threats to global healthcare. Infections that were once routinely treatable increasingly survive first-line therapy, while the discovery pipeline for genuinely novel antibacterial agents has slowed to a near halt. MRSA is linked to close to 50,000 deaths annually...
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