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Open access Aug 2026

Longitudinal Motor Trajectories and 2-Year Cognitive and Functional Outcomes in First-Episode Psychosis.

Sustained hyperkinetic severity was consistently associated with poorer verbal memory and functional outcome over time, supporting the relevance of MAs as longitudinal correlates of cognitive and functional variability in early psychosis.

E. Giné-Servén, G. Gil-Berrozpe, A. Ballesteros et al. · 0 citations
Open access Sep 2026

Two-year domain-specific cognitive trajectories following a first episode of psychosis and early intervention: A data-driven study.

BACKGROUND AND HYPOTHESIS Cognitive impairment is a core feature of psychotic disorders and predicts long-term outcomes. However, cognitive trajectories following first-episode psychosis (FEP) are heterogeneous. We hypothesized the presence of distinct global and domain-specific cognitive trajectories over two years, w...

An-Qun Leng, Olivier Percie du Sert, M. Lepage et al. · 0 citations
Open access Oct 2026

Prospective Bidirectional Associations Between Core Schemas, Attenuated Psychotic Symptoms, and Functioning in Youth at Clinical High Risk for Psychosis

Objective: Cognitive models of psychosis implicate maladaptive core schemas in the development and emergence of psychotic symptoms, but no study has tested temporal dynamics between schemas and psychotic symptoms in a large sample of clinical high-risk (CHR) youth. Given their sizable role in cognitive behavioral thera...

A. Broekhuijse, A. Saxena, C. Mourgues-Codern et al. · 0 citations
Open access Sep 2026

Patterns, predictors and outcomes of the joint trajectories of positive and negative symptoms in patients with early psychosis: 12-year follow-up of the randomized controlled trial on extended early intervention.

BACKGROUND Positive and negative symptoms are considered core features of psychotic disorders. However, no study has identified joint trajectories of positive and negative symptoms in early psychosis with long-term follow-up. METHOD We conducted 12-year follow-up of a randomized-controlled trial on extended early int...

Chris Chit Sze Fung, Ryan Sai-Ting Chu, Natalie Wing Tung Chu et al. · 0 citations
Open access Sep 2026

Early-stage trajectories of social-occupational functioning and long-term functional outcome prediction in early psychosis: A 12-year follow-up of the randomized controlled trial on extended early intervention

Findings highlighted the importance of tracking functional changes during the initial years of illness, and identified four distinct trajectories, including persistently-good class, gradually-improved class, suboptimal-stable class, and persistently-poor class.

Natalie Wing Tung Chu, Ryan Sai-Ting Chu, Chris Chit Sze Fung et al. · 0 citations
Open access Aug 2026

Mapping 20-Year Global Functioning Trajectories in Schizophrenia Spectrum Disorders.

At the 20-year follow-up, individuals in the Functional recovery trajectory demonstrated the most favorable outcomes, while those in the Impaired functioning trajectory exhibited the poorest outcomes across all key domains.

M. Abella, H. G. Hansen, C. Hjorthøj et al. · 0 citations

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