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EF-1α-driven nanobody-based CD19-redirected CAR-T cells retain the antitumor efficacy, antigen-driven expansion, and cytokine secretion of CMV-driven counterparts

Marzieh Mazinani Pooria Safarzadeh Kozani F. Rahbarizadeh
Jul 2026 · Molecular and Cellular Biochemistry · Vol 481, pp. 3733 - 3746 · 0 citations · 42 references
Medicine

TL;DR

EF-1α preserved the antitumor potency of nanobody-based CD19-redirected CAR-T cells, supporting its use as a clinically relevant promoter for further development of this VHH-based CAR-T cell platform.

DOI PubMed Semantic Scholar
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