It is suggested that YY1 preserves B cell identity through coordinated regulation of transcriptional and post-transcriptional programs, with YY1-dependent miRNA networks contributing to the maintenance of B cell-associated gene expression and restriction of alternative lineage programs.
Post-transcriptional control by RNA binding proteins (RBPs) and microRNAs play central roles in mRNA stability and translation, yet how RBPs and microRNAs coordinate in developmental time to regulate cell fate remains poorly understood. Here, we demonstrate that post-transcriptional regulation of the Profilin 2 (Pfn2)...
Carolyn Sangokoya, Isabella R. Rosso, Rana Ghandehari-Alavijeh et al.· PLoS Genetics· 0 citations
A unified mechanistic framework by which the level of YAP/TAZ activity determines enhancer landscapes that favor either differentiated or progenitor-like cellular states is proposed, providing a potential basis for applications to regenerative medicine and therapeutic interventions.
Ju-Gyeong Kang, Taejun Seol, Younghoon Kim et al.· Cold Spring Harbor Perspecti...· 0 citations
Autophagy plays a critical role in maintaining cellular homeostasis and regulating stem cell fate. Although microRNAs (miRNAs) are being increasingly recognized for their ability to modulate autophagy and pluripotency in human pluripotent stem cells (hPSCs), the underlying molecular mechanisms remain incompletely under...
Xing Zhen, Hyebin Koh, Dong-Seok Lee et al.· Signal Transduction and Targ...· 0 citations
Significance Despite the established role of Rbp-Jκ as the master transcriptional regulator of Notch signaling, its cell-intrinsic functions in natural killer (NK) cells remain unknown. In this study, we integrate genetic ablation (Ncr1iCre × Rbp-Jκfl/fl) studies with scRNA-seq, scATAC-seq, bulk ATAC-seq, CUT&Tag, and...
Hongyan Peng, Yao Yang, Yongjie Liu et al.· Proceedings of the National...· 0 citations
Abstract LIN28A is a conserved RNA-binding protein essential for pluripotency, let-7 miRNA regulation, and cellular metabolism. However, the mechanisms controlling its transcriptional activation during early stem cell fate transitions remain poorly defined. Using the Lin28a locus as a model, we identified multiple intr...
It is revealed that transcription of aak-1/AMPK is necessary to silence transcription in quiescent PGCs, and it is validated PGC transcription of aak-1/AMPK, and it is showed that zygotic aak-1/AMPK is required for PGC chromatin hyper-compaction, supporting reproductive success upon recovery.
Jing-Xian Chen, Sharan Surya, R. Chitrakar et al.· bioRxiv· 0 citations
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