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Progression to Dementia in Very Late‐Onset Schizophrenia‐Like Psychosis Stratified by Alzheimer's Disease and Lewy Body Disease Biomarkers: A Retrospective Cohort Study

Y. Satake H. Kanemoto Daiki Taomoto Kayo Takeda Shigeki Katakami Matasaburo Kobayashi K. Matsunaga K. Isohashi Takashi Suehiro K. Yoshiyama Manabu Ikeda

Aug 2026 · Psychogeriatrics · Vol 26 · 0 citations · 41 references

Medicine

TL;DR

AD and/or LBD biomarker‐positive VLOSLP may be associated with greater dementia progression and cognitive decline, although findings should be interpreted cautiously given the small sample size and retrospective design.

Abstract

Very late‐onset schizophrenia‐like psychosis (VLOSLP) is clinically heterogeneous, and its relationship with dementia‐related neurodegenerative disease remains unresolved. We examined whether Alzheimer's disease (AD) and Lewy body disease (LBD) biomarker status were associated with dementia progression in VLOSLP.

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