Sep 2026· Journal of Infectious Diseases· 0 citations
Medicine
TL;DR
A global panel of natural infection sera and relational antigenic maps is used to assess HPV33 and HPV45 neutralizing antibody specificity to inform the degree of lineage and sublineage specificity within the natural infection humoral immune response to oncogenic HPV.
Epstein-Barr virus (EBV) is a widespread human herpesvirus linked to several malignancies, yet no vaccine has been approved. Its major surface glycoprotein, gp350, mediates attachment to B cells via CR2 binding, but gp350-based vaccines have shown limited protection, raising questions about its neutralizing epitopes an...
ABSTRACT A phase I study was conducted in 20 healthy subjects with 20 µg adeno-associated virus 2 (AAV2)-like particles displaying L2 residues 17–36 of both human papillomavirus (HPV) type 16 and HPV31 (AAVLP-HPV) or placebo. AAVLP-HPV vaccination was well tolerated and induced a modest L2-specific serum antibody titer...
Jade Alvarez, Pola Olczak, Hua-Ling Tsai et al.· Journal of Virology· 0 citations
Persistent infection with high-risk human papillomavirus, particularly HPV16, is a major cause of cervical cancer and orogenital malignancies. Therapeutic DNA vaccines targeting viral oncoproteins represent a promising strategy to induce antitumor immune responses. However, the impact of antigen combinations in bicistr...
Ingrid Andrêssa de Moura, Karina Mayumi Tani Bezerra de Melo, L. R. S. Leal et al.· Molecules· 0 citations
Licensed human papillomavirus (HPV) vaccines do not target cutaneous genus beta (ß)HPV types implicated in skin cancer development in immunosuppressed individuals. The conserved N-terminus of minor capsid protein offers the opportunity to develop broad-spectrum vaccine candidates. We employed a sequential immunizatio...
The inability to perform forward genetics has been a major barrier to human papillomavirus (HPV) research. Here, we report a platform for phenotypic selection of HPV mutants. Our method relies on large “concordant” virus libraries, where each mutant virus particle encapsidates the mutant plasmid that encodes it, thereb...
Yuka Takeo, Sydney R. Hirsch, Daniel DiMaio· Science Advances· 0 citations
Using pseudovirus particles, it is shown that subclade K-HA drives augmented entry into certain cell lines and displays significant antibody evasion, suggesting that current vaccines may provide considerable protection.
Nicole Moor, N. Chen, G. Behrens et al.· npj Vaccines· 0 citations
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