IA & Biotechnologies Multi-omiques pour la Santé, la Longévité et la Bioproduction

Abstract

Abstract ENThis document, produced with the assistance of ChatGPT o3 and GPT-5 Thinking, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes (art. L 611-11 CPI / art. 54(2) CBE; cf. 35 U.S.C. §102(a)). We disclose 130 enabling inventions spanning clinical multi-omics integration, explainable multimodal models, digital twins, closed-loop bioprocess control, frugal AMR sentinels, HL7/FHIR/DICOM interoperability, privacy-preserving/federated learning, IVDR/AI-Act-ready MLOps and governance, pre-analytical logistics and QC, and Green-AI/ESG methods. Every proposal is described in an enabling manner, classified with IPC and CPC codes, and supported by timestamp proof (RFC 3161 / FreeTSA) to pre-empt overlapping patent claims while guiding open, safe, and interoperable innovation. Résumé FRCe document, produit avec l’assistance de ChatGPT o3 et GPT-5 Thinking, est publié sous la licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre de ce fait dans l’état de la technique au sens des législations applicables (EPC Art. 54(2) ; French IPC Art. L 611-11 ; cf. 35 U.S.C. §102(a)). Sont divulguées 130 inventions « enabling » couvrant l’intégration clinique multi-omique, des modèles multimodaux explicables, des jumeaux numériques, le contrôle en boucle des bioprocédés, des sentinelles AMR frugales, l’interopérabilité HL7/FHIR/DICOM, l’apprentissage fédéré et la confidentialité, des chaînes MLOps IVDR/AI-Act, la logistique pré-analytique et la qualité, ainsi que des méthodes Green-AI/ESG. Chaque proposition est reproductible, classée (IPC/CPC) et horodatée (RFC 3161 / FreeTSA) afin de préempter des revendications futures et d’encourager une innovation ouverte et interopérable. Timestamp: 2025-10-12T17:00:39ZSHA-256: 16fa4b2f4c8e8d4023ab958117c1b5da26b6202d1960f8305fe328c2000de66c Liste des innovations & classification (IPC ; CPC)1. Patient digital twin platform — IPC G16H 50/20 ; CPC G16H 40/202. Pan-pathogen saliva test — IPC C12Q 1/68 ; CPC G01N 33/5693. Metabolic patch sensor — IPC A61B 5/145 ; CPC G01N 33/4974. Adaptive trial design AI — IPC G06N 20/00 ; CPC G16H 50/305. Low-dose imaging with physics QA — IPC G06T 7/60 ; CPC A61B 6/006. Early sepsis detection EHR+omics — IPC G16H 50/20 ; CPC A61B 5/007. Liver–tumor targeted LNPs — IPC A61K 9/127 ; CPC C12N 15/1138. Normalized therapeutic exosomes — IPC C12Q 1/6886 ; CPC A61K 35/129. Federated trial orchestrator — IPC G06F 21/62 ; CPC G06N 20/1010. Closed-loop infusion control — IPC A61M 5/168 ; CPC G05D 1/0211. Pre-analytic omics kit — IPC C12N 15/10 ; CPC C12Q 1/680612. Tumor microenvironment atlas — IPC G16B 40/20 ; CPC G06F 16/245413. Bioproduction lot OOS detector — IPC C12M 1/34 ; CPC G05B 23/0214. Learning neuroprosthesis — IPC A61B 34/00 ; CPC A61F 2/6815. Degradable peptide design AI — IPC G06N 3/08 ; CPC C07K 14/0016. Verifiable cold-chain twin — IPC G08C 17/02 ; CPC G06Q 10/0817. Portable imaging triage — IPC A61B 8/00 ; CPC G06T 7/7318. Chrono-guided combo therapy — IPC A61P 43/00 ; CPC G16H 20/1019. Multi-omics interoperability — IPC G16H 10/60 ; CPC G06F 21/6220. Pulsatile MEMS drug implant — IPC A61M 37/00 ; CPC B81C 99/0021. Pediatric dose reduction imaging — IPC A61B 6/00 ; CPC G06T 7/6022. Calibration-as-a-Service — IPC G01N 30/86 ; CPC G06Q 50/2623. Anti-biofilm bio-inspired coating — IPC A61L 29/08 ; CPC C08L 33/0024. Clinical model auditability — IPC G06F 11/36 ; CPC G06N 20/1025. CRISPR off-target assay — IPC C12Q 1/6848 ; CPC C12Q 1/688626. Inducible cellular kill-switch — IPC C12N 15/90 ; CPC C12N 15/11327. Multi-omics organ-on-chip — IPC C12M 3/00 ; CPC G01N 33/5028. Private synthetic omics data — IPC G06F 21/62 ; CPC G06N 20/0029. Consent ledger for clinico-omics — IPC G16H 10/60 ; CPC H04L 9/3230. Edge QC for nanopore — IPC C12Q 1/68 ; CPC G01N 33/6831. Single-use bioreactor film sensors — IPC C12M 1/34 ; CPC G01N 33/5032. RL lab robotics scheduler — IPC G06N 20/00 ; CPC G05B 19/41833. Online adaptive radiotherapy — IPC A61N 5/10 ; CPC G06T 7/6034. Inhalable dry-powder LNPs — IPC A61K 9/14 ; CPC A61K 9/12735. Intention-aware EMG exoskeleton — IPC A61F 5/56 ; CPC A61B 5/1136. AI for bispecific antibodies — IPC C07K 16/00 ; CPC G06N 3/0837. On-device ECG transformer — IPC G16H 50/20 ; CPC G06N 20/0038. Breath VOC spectrometry — IPC G01N 33/497 ; CPC A61B 5/0039. Microbial consortia control — IPC C12M 1/34 ; CPC G05D 1/0240. Base/prime editing QC — IPC C12Q 1/6848 ; CPC C12Q 1/688641. Non-invasive uremia patch — IPC A61B 5/00 ; CPC G01N 33/6842. Digital pathology QA — IPC G06T 7/00 ; CPC G16H 40/6743. Omics solvent recycling — IPC B01D 3/00 ; CPC G05B 19/409344. GMP digital thread — IPC G05B 19/418 ; CPC G06F 11/3645. Causal RWE engine — IPC G06F 17/30 ; CPC G16H 50/3046. Synthetic control arms — IPC G06F 17/30 ; CPC G06N 20/0047. dMRI motion correction — IPC G06T 7/60 ; CPC A61B 5/05548. Adaptive proton planning — IPC A61N 5/10 ; CPC G06T 7/6049. Edge genomic compression — IPC G06F 3/06 ; CPC H03M 7/4650. Semantic ETL to FHIR-Omics — IPC G16H 10/60 ; CPC G06F 16/2851. Cuffless blood pressure — IPC A61B 5/024 ; CPC G01N 33/49752. Contrast dose personalization — IPC A61B 6/00 ; CPC G06T 7/6053. On-device de-identification — IPC G06F 21/62 ; CPC G16H 10/6054. Index-hopping contamination — IPC C12Q 1/6811 ; CPC C12Q 1/688655. Robotic safe phlebotomy — IPC A61M 5/36 ; CPC G05B 19/41856. Adaptive multi-sensor ventilation — IPC A61M 16/00 ; CPC G05D 1/0257. Microneedle ISF omic sampling — IPC A61M 37/00 ; CPC C12Q 1/680658. Intra-op hyperspectral AR — IPC A61B 5/00 ; CPC G06T 7/7359. Granular consent UX — IPC G16H 10/60 ; CPC H04L 9/3260. Lab cold recovery — IPC F25B 49/02 ; CPC F24F 12/0061. Smart sterilization indicators — IPC A61L 2/28 ; CPC G01N 31/2262. Universal transport buffer — IPC C12Q 1/6806 ; CPC C12N 15/1063. DNA watermark traceability — IPC C12N 15/10 ; CPC C12Q 1/688664. Dataset provenance graph — IPC G06F 11/36 ; CPC G06F 16/245465. Synthetic data benchmarks — IPC G06F 17/30 ; CPC G06N 20/0066. Medical cold-chain drone — IPC B64C 39/02 ; CPC B64U 10/1067. Health edge HSM — IPC H04L 9/32 ; CPC G06F 21/5768. OR scheduling AI — IPC G06N 20/00 ; CPC G06Q 50/2669. Urine strip spectrometry — IPC G01N 33/52 ; CPC A61B 5/0070. Weak-signal ambulatory EEG — IPC A61B 5/048 ; CPC G06N 20/0071. AAV empty/full inline — IPC C12Q 1/70 ; CPC G01N 30/8672. PAT Raman bioprocess — IPC G01N 21/65 ; CPC C12M 1/3473. Targeted glyco-engineering — IPC C12N 15/90 ; CPC C12P 21/0274. IA-optimized CIP/SIP — IPC A61L 2/28 ; CPC G05B 19/41875. Gradient cryopreservation — IPC C12N 5/10 ; CPC C12N 5/08176. Microfluidic endotoxin test — IPC G01N 33/574 ; CPC C12Q 1/0477. GMP fill-finish vision — IPC B65B 59/00 ; CPC G06T 7/7378. OCT bioprinting QC — IPC B33Y 80/00 ; CPC G01N 21/4579. TAVI hemodynamic twin — IPC A61B 6/00 ; CPC G06T 7/6080. Pressure-sensing stent — IPC A61F 2/82 ; CPC G01L 9/1281. Rare-disease triage engine — IPC G16H 50/20 ; CPC G06N 20/0082. Inter-lab LC-MS normalization — IPC G01N 33/68 ; CPC C12Q 1/688683. Barcoded pool deconvolution — IPC C12Q 1/6848 ; CPC G06F 17/3084. Vector stability prediction — IPC A61K 48/00 ; CPC G06N 20/0085. PK/PD TDM-guided dosing — IPC A61P 43/00 ; CPC G16H 20/1086. Constraint-aware LIMS inventory — IPC G06Q 10/08 ; CPC G16H 10/6087. Wearable cough analysis — IPC A61B 5/08 ; CPC G10L 25/6388. Calibrated portable PCR — IPC C12Q 1/16 ; CPC B01L 7/0089. RBC enzyme hitchhiking — IPC A61K 38/00 ; CPC A61K 9/12790. Magnetic selection with feedback — IPC C12N 5/06 ; CPC B01L 3/502791. Clinical feature store — IPC G06F 16/2454 ; CPC G16H 10/6092. Transcutaneous Raman metabolites — IPC G01N 21/65 ; CPC A61B 5/14593. Thermostable spray-dried vaccine — IPC A61K 39/00 ; CPC A61K 9/1494. Text-mined adverse events — IPC G16H 50/20 ; CPC G06F 17/3095. Antifoam bioreactor control — IPC C12M 1/34 ; CPC G05D 1/0296. Smartphone fundus imaging — IPC A61B 3/10 ; CPC G06T 7/6097. Photoacoustic sterilant monitor — IPC A61L 2/26 ; CPC G01N 21/1798. Biologics stability ML — IPC G01N 33/68 ; CPC G06N 20/0099. Clinical AI ethics cockpit — IPC G06N 20/00 ; CPC G16H 50/30100. Decentralized self-sampling kit — IPC G01N 33/49 ; CPC H04L 9/32101. Multimodal AI imaging+omics Dx — IPC G06N 20/00 ; CPC G16H 50/30102. Integrated longevity score — IPC G16H 40/20 ; CPC A61B 5/00103. Multi-omic foundation model — IPC G06N 3/04 ; CPC G06N 20/10104. Active learning for studies — IPC G06N 20/00 ; CPC G06F 18/24105. GxP MLOps ready for CE/IVDR — IPC G16H 20/10 ; CPC G16H 40/67106. Explainable radiogenomics — IPC G06T 7/00 ; CPC G16H 50/70107. Paper kit + smartphone app — IPC G01N 33/50 ; CPC G16H 40/67108. Isolated clinical edge-AI — IPC A61B 5/00 ; CPC G16H 40/67109. Automated omics QA/QC — IPC G01N 1/00 ; CPC G16H 10/60110. Zero-waste AI bioprocess — IPC C12P 21/00 ; CPC G05B 13/02111. Scientist-safe RLHF — IPC G06N 20/00 ; CPC G06F 18/24112. Health–environment city sentinel — IPC G16H 40/20 ; CPC G16H 40/63113. Omics→image spatial rendering — IPC G06T 7/00 ; CPC G16H 50/70114. Bioreactor digital twin — IPC G05B 13/02 ; CPC C12P 21/00115. Spatial-omics scanner adapter — IPC G01N 33/68 ; CPC C12Q 1/6886116. Explainable pathogenicity report — IPC G16B 40/20 ; CPC G16H 50/70117. Microbiome response predictor — IPC G16H 50/20 ; CPC G16H 40/67118. TEE “safe haven” for FHIR — IPC G06F 21/62 ; CPC G16H 10/60119. Carbon-aware AI scheduler — IPC G06F 9/50 ; CPC Y02B 70/12120. Sequencer run scheduler — IPC G06F 9/50 ; CPC Y02B 70/12121. HPO/LOINC/SNOMED harmonizer — IPC G16H 10/60 ; CPC G16H 40/20122. Hospital domain adaptation — IPC G16H 20/10 ; CPC G16H 50/70123. Executable data contracts — IPC G06F 16/28 ; CPC G16H 10/60124. DICOM↔FHIR radiogenomics bridge — IPC G16H 10/60 ; CPC G06T 7/00125. IVDR risk dashboard — IPC G16H 20/10 ; CPC G16H 40/67126. Clinical fairness auditor — IPC G16H 50/70 ; CPC G16H 40/67127. Fr