Rapport sur le déploiement du marché des fullerènes endohédraux Ag@C60
Abstract
Résumé FRCe document, produit avec l’assistance de ChatGPT 5.2 Thinking et Gemini 3 Raisonnement, est publié sous licence Apache 2.0. Il constitue une publication défensive (antériorité) et entre de ce fait dans l’état de la technique au sens des législations applicables : EPC Art. 54(2); French IPC Art. L 611-11; cf. 35 U.S.C. §102(a); Loi chinoise sur les brevets art. 22(5) (中华人民共和国专利法) et Loi japonaise sur les brevets art. 29(1) (特許法). Il divulgue de façon enabling des procédés de synthèse/purification d’Ag@C60 (arc, ablation laser, HPLC, centrifugation/CPC, recyclage solvants et argent), des méthodes QA/qualification (MS, HPLC, ICP, empreintes spectrales, TEM-EDX, tests extrêmes), et des systèmes applicatifs pour diagnostic ultra-précoce (biosenseurs plasmoniques, kits, CT/dual-modality, IA) et maintenance prédictive aérospatiale (revêtements capteurs, smart paint, jumeau numérique, apprentissage fédéré, ordonnancement). Chaque proposition est classifiée IPC/CPC et accompagnée d’une preuve d’horodatage (RFC 3161 / FreeTSA). Abstract ENThis document, produced with the assistance of ChatGPT 5.2 Thinking and Gemini 3 Raisonnement, is released under the Apache 2.0 licence. It is a voluntary defensive publication (prior art) and therefore enters the prior art upon release under the applicable patent statutes: (art. L 611-11 CPI / art. 54(2) CBE), 35 U.S.C. §102(a) (United States Patent Act), Chinese Patent Law Art. 22(5) (中华人民共和国专利法), and Japanese Patent Act Art. 29(1) (特許法). It enables Ag@C60 endohedral-fullerene production and deployment across (i) synthesis and purification (arc discharge, laser ablation, preparative HPLC, density-gradient/continuous centrifugation, CPC, solvent and silver recycling), (ii) QA and qualification (HR-MS, analytical HPLC, ICP-MS free-metal release, multimodal spectral fingerprints, TEM-EDX encapsulation proof, extreme pressure/thermal/vibration tests), and (iii) applications in ultra-early diagnostics (plasmonic biosensors, standardized kits, CT/dual-modality imaging, AI reconstruction) and aerospace predictive maintenance (conductive coatings, smart paint, telemetry standards, digital twins, federated learning, closed-loop scheduling). Each proposal is enabling, IPC/CPC-classified, and timestamped (RFC 3161 / FreeTSA). Timestamp: 2026-01-01T12:33:29ZSHA-256: 5345e809e5c8bdd4aa23bcd8be10378538249bef505715d9fee259cb2448a06b Liste des innovations & classification (IPC ; CPC)1. Ag@C60 arc process mapping — IPC C01B 31/02 ; CPC C01B 31/022. Ag@C60 laser target recipe — IPC C01B 31/02 ; CPC C01B 31/023. Low-oxygen composite anode — IPC C01B 31/02 ; CPC C01B 31/024. Green extraction with recycling — IPC B01D 11/04 ; CPC B01D 11/045. Multi-column prep HPLC line — IPC B01D 15/08 ; CPC B01D 15/086. Density-gradient ultracentrifugation — IPC B04B 1/00 ; CPC B04B 1/007. Continuous-flow centrifugation — IPC B04B 9/00 ; CPC B04B 9/008. Silver recovery from residues — IPC C22B 3/00 ; CPC C22B 3/009. 99.9% multi-tech QC release — IPC G01N 30/74 ; CPC G01N 30/7410. Extreme-pressure cage test — IPC G01N 3/08 ; CPC G01N 3/0811. Vibration/thermal cage qualification — IPC G01M 7/00 ; CPC G01M 7/0012. Flexible SPCE Ag@C60 biosensor — IPC G01N 21/64 ; CPC G01N 21/6413. Pre-analytical standard kit — IPC C12Q 1/68 ; CPC C12Q 1/6814. Ag@C60 lateral-flow label — IPC G01N 33/53 ; CPC G01N 33/5315. PEGylated Ag@C60 CT contrast — IPC A61K 9/127 ; CPC A61K 9/12716. Low-dose CT reconstruction AI — IPC G06N 20/00 ; CPC G06T 7/0017. Dual-modality CT+NIR workflow — IPC A61B 6/00 ; CPC A61B 6/0018. Turbine crack-sensing coating — IPC G01L 1/22 ; CPC G01L 1/2219. RFID smart paint SHM network — IPC G01M 13/00 ; CPC G01M 13/0020. EMF fleet digital twin — IPC G06Q 10/06 ; CPC G06Q 10/0621. Federated learning across fleets — IPC G06N 20/00 ; CPC G06F 21/6222. Closed-loop maintenance scheduler — IPC G06Q 10/08 ; CPC G06Q 10/08323. Diagnostic micro-dose protocol — IPC A61K 31/00 ; CPC A61K 31/0024. Liposomal Ag@C60 injectable — IPC A61K 9/127 ; CPC A61K 9/12725. Oral oil Ag@C60 formulation — IPC A61K 9/08 ; CPC A61K 9/0826. Microneedle patch closed-loop — IPC A61M 37/00 ; CPC A61M 37/0027. Anti-inflammatory implant coating — IPC A61L 27/00 ; CPC A61L 27/0028. Ag@C60 photothermal theranostics — IPC A61N 5/06 ; CPC A61N 5/0629. Antimicrobial photodynamic hydrogel — IPC A61L 2/18 ; CPC A61L 2/1830. Nanoparticle LCA dashboard — IPC G06Q 50/00 ; CPC G06Q 50/0631. DICOM-EMF metadata extension — IPC G16H 10/60 ; CPC G16H 10/6032. Secure aerospace telemetry schema — IPC G06F 16/00 ; CPC G06F 16/2733. Clinical triage workflow UX — IPC A61B 5/00 ; CPC G16H 40/6734. Explainable MRO alerts UI — IPC G06Q 10/08 ; CPC G06Q 10/08335. Traceable solvent/lot packaging — IPC B65D 55/02 ; CPC B65D 55/0236. Cold-chain for formulations — IPC G06Q 10/08 ; CPC G06Q 10/08337. Calibration-as-a-service metrology — IPC G06Q 10/06 ; CPC G06Q 10/06338. Performance-based MRO contracting — IPC G06Q 40/08 ; CPC G06Q 40/0839. Closed-loop helium for arcs — IPC F17C 11/00 ; CPC F17C 11/0040. CO ventilation safety interlock — IPC G08B 21/00 ; CPC G08B 21/0041. Automated moving anode feed — IPC H05B 7/18 ; CPC H05B 7/1842. OES plasma closed-loop control — IPC G01N 21/63 ; CPC G01N 21/6343. Ni/Cu catalytic anode dopant — IPC C01B 31/02 ; CPC C01B 31/0244. Antisolvent colloid generator — IPC B04B 1/00 ; CPC B04B 1/0045. Vacuum distillation solvent recycle QA — IPC B01D 3/14 ; CPC B01D 3/1446. Temperature-controlled centrifugation — IPC B04B 15/00 ; CPC B04B 15/0047. Continuous CPC fullerene separation — IPC B01D 15/08 ; CPC B01D 15/0848. C60/C70 coproduct monetization — IPC C01B 31/02 ; CPC C01B 31/0249. TEM-EDX encapsulation proof QC — IPC G01N 23/04 ; CPC G01N 23/0450. Multimodal spectral lot fingerprint — IPC G01N 21/27 ; CPC G01N 21/2751. Formulation-dependent PK protocol — IPC A61K 9/127 ; CPC A61K 9/12752. Fullerene wastewater capture train — IPC C02F 1/28 ; CPC C02F 1/2853. Sealed QA sample chain-of-custody — IPC G06Q 10/08 ; CPC G06Q 10/08354. MeTHF antisolvent gradient — IPC B04B 1/00 ; CPC B04B 1/0055. Terpene solvent screening SOP — IPC G01N 30/74 ; CPC G01N 30/7456. C60 coproduct crystallization line — IPC C01B 31/02 ; CPC C01B 31/0257. Modular parallel arc CAPEX design — IPC H05B 7/18 ; CPC H05B 7/1858. Arc heat recovery to distillation — IPC F28D 1/00 ; CPC F28D 1/0059. Inline ICP micro-sampling — IPC G01N 21/85 ; CPC G01N 21/8560. Lipid droplet loading uniformity — IPC A61K 9/127 ; CPC A61K 9/12761. Passive PEGylated liposomes — IPC A61K 9/127 ; CPC A61K 9/12762. Injectable MCT nanoemulsion — IPC A61K 9/127 ; CPC A61K 9/12763. Vitamin E co-formulation — IPC A61K 31/355 ; CPC A61K 31/35564. CoQ10/melatonin co-formulation — IPC A61K 31/35 ; CPC A61K 31/3565. Porphyrin--Ag@C60 PDT complex — IPC A61N 5/06 ; CPC A61N 5/0666. Ag@C60 FRET ROS sensor — IPC G01N 21/64 ; CPC G01N 21/6467. Core--shell heating + scavenging — IPC A61N 5/06 ; CPC A61N 5/0668. Protected radiosensitization method — IPC A61N 5/10 ; CPC A61N 5/1069. Mitochondrial organelle imaging — IPC A61B 6/00 ; CPC A61B 6/0070. Ag@C60-doped neural electrode — IPC A61N 1/36 ; CPC A61N 1/3671. Light-activated antibiofilm implant — IPC A61L 2/18 ; CPC A61L 2/1872. Dual-mode LED wound dressing — IPC A61L 15/44 ; CPC A61L 15/4473. Standardized multi-form tox panel — IPC G01N 33/50 ; CPC G01N 33/5074. Carbide/alloy low-O2 anode feed — IPC C01B 31/02 ; CPC C01B 31/02 KeywordsMeTHF antisolvent gradient, terpene solvent screening, C60 crystallization coproduct, modular arc reactors, heat recovery distillation, inline ICP-MS free metal, droplet loading homogeneity, PEGylated liposomes, MCT injectable emulsion, vitamin E coformulation, CoQ10 melatonin synergy, porphyrin complex PDT, FRET ROS sensor, core-shell plasmonic heating, protected radiosensitization, mitochondria organelle imaging, neural electrode composite, implant antibiofilm photothermal, dual-mode LED wound dressing, formulation-dependent toxicology, metal-carbide electrode
