Infection with Western equine encephalitis virus causes severe regional glial reactivity and neurodegeneration in the hippocampus with progressive accumulation of amyloid-β.

Aidan M. Briggs Adam J. Schuller Megan R. Hager Omar A. Yanouri Savannah M. Rocha C. Bantle Debotri Chatterjee R. Smeyne Ronald B. Tjalkens

Aug 2026 · Journal of Neuropathology and Experimental Neurology · 0 citations

Medicine

TL;DR

A longitudinal assessment of hippocampal pathology following intranasal infection with McMillan WEEV defines a dynamic sequence of glial activation, lesion formation, and protein aggregation underlying WEEV-induced hippocampal neurotoxicity.

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