Aug 2026· Molecular Diagnosis & Therapy· 0 citations· 249 references
Medicine
TL;DR
How cells balance this tightrope between adaptation and cell death in the context of cancer is dissected, and how UPR signaling drives angiogenesis, metastasis, immune-evasion, and chemoresistance is explored before finally discussing its therapeutic potential.
This review integrates recent mechanistic insights into UPR-driven tumor progression, including pathway crosstalk, immune regulation, and immunotherapy resistance, with advances in small-molecule inhibitors, while critically evaluating their therapeutic potential and translational challenges in cancer treatment.
Meizhen Lin, Zhijie Li· Frontiers in Immunology· 0 citations
This review summarizes how the three canonical UPR branches establish a persistent adaptive state under chronic ER stress and discusses the molecular mechanisms by which UPR signaling maintains proteostasis, reprograms cellular metabolism, alleviates oxidative stress, and coordinates autophagy.
Zihe Zhou· Theoretical and Natural Scie...· 0 citations
Current evidence is brought together to provide a comprehensive understanding of how CMA contributes to the Hallmarks of Cancer, including sustained proliferative signaling, resistance to cell death, metabolic reprogramming, invasion and metastasis, immune evasion, and the enabling characteristics of genome instability...
Meenakshi Tiwari, Lokendra Kumar Sharma, Bandana Chakravarti et al.· Frontiers in Oncology· 0 citations
Findings reveal a metabolic adaptation in NEPC and provide preclinical evidence that co-targeting PIKfyve and FASN can overcome hypoxia-associated stress adaptation.
Yang Zheng, Caleb Cheng, Yizhi Cao et al.· Cancer Cell· 0 citations
This review analyzes how the ubiquitin–proteasome system, autophagy–lysosome pathway, endoplasmic reticulum stress‐induced unfolded protein response signaling, and molecular chaperone networks are differentially reconfigured in cancer and cardiac tissues, influencing tumor survival, therapeutic susceptibility, and card...
Jacob Eli García Torres, Norbert Frey, A. Rangrez· MedComm· 0 citations
In insights on the research regarding therapeutic approaches of NDs which intend to target molecular components, a general understanding of proteostasis, ER stress, UPR signalling and how these cellular processes are related to neurodegeneration is provided.
E. Çoban, A. Cerkezkayabekir· Neurochemical Journal· 0 citations
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