Background. Large language models (LLMs) have been rapidly adopted in medicine since late 2022, yet their role in the time-critical acute stroke pathway—from symptom recognition and prehospital triage to emergency diagnosis, imaging-related text tasks, reperfusion decision support, and acute-phase documentation and communication—has not been systematically mapped. Existing reviews cover the whole stroke-care continuum or mix LLMs with traditional NLP, leaving the acute phase under-characterized. Objective. To map the applications, evidence maturity, and implementation readiness of LLMs across the acute stroke pathway. Methods. This scoping review follows the PRISMA-ScR guideline. We search PubMed/MEDLINE, Europe PMC (including preprints), and Google Scholar for studies published from November 2022 onward. Eligible studies center on LLMs/generative AI applied to any stage of the acute stroke pathway. Two reviewers independently screen records and chart data using a piloted form. Evidence is synthesized along two dimensions: five pathway stages (prehospital recognition/dispatch; emergency triage and differential diagnosis; imaging-related text tasks; reperfusion decision support; acute documentation and communication) and three evidence-maturity tiers (simulation/benchmark; retrospective real-world data; prospective deployment). Implementation barriers (hallucination, bias, privacy, regulation, liability, integration, cost) are thematically summarized. Registration note. This review is registered on OSF; the full protocol is available in the attached files.
A production platform built on large language models makes two kinds of decision, and most of its trouble comes from writing both into one clause. An optimization decision improves an objective: lower latency, lower cost, higher quality, fewer tests run. A boundary decision fixes a constraint that may not be relaxed for any gain: a residency rule, a least-privilege scope, a human-review threshold. When the two share a clause, improving one silently erodes the other, which is why efficiency and accountability are so often reported as a trade. This specification is built on one invariant: a boundary is a clause the optimizer may not cross, and everything else is optimization. The contribution is a cross-layer architectural method for separating non-negotiable constraints from adaptive optimization and binding both to reconstructable evidence, applied identically across model routing, agent orchestration and AI-native delivery. The seventeen patterns are instances of that method rather than the contribution itself. Each pattern is specified in the classical pattern form and carries three architectural declarations: the boundary it fixes, the optimizer it frees, and the evidence proving the boundary held. Every boundary is assigned to one of five classes covering data, authority, decision, resource and process constraints. Section 3 states the derivation method by which candidates were admitted or rejected, and publishes the rejections alongside the admissions so that the criterion can be examined rather than trusted. Three mechanisms make the language operate as a language rather than a list. A pattern relationship graph names which pattern supplies the artifact, evidence or authority another depends on, including the single cycle by which a workflow improves from its own structural record and the economic chain running the full height of the stack. A normative event identity, with rules for causal parentage, retries, provider boundaries and retention, turns the requirement that evidence be joinable into something an implementation can satisfy or fail. And per-pattern applicability conditions replace categorical requirements, so that a pattern governing a mechanism an institution does not operate is out of scope rather than a gap. Conformance is self-declared and published as a profile carrying the environment, the applicable set, per-pattern status, an evidence date and documented gaps. It is not a certification scheme, and no conformity assessment body operates against it. The contribution is architectural rather than empirical. Every pattern carries an evidence level, and no pattern reaches the highest level, because no implementation unconnected to the author has been evaluated. Nothing has been measured. The specification separates what would falsify the invariant from what would falsify an individual pattern and from what would falsify the composition and adoption sequence, poses six research questions, and records the absence of a real implementation profile as a known deficiency of version 1.0. An appendix reconciles the pattern identifiers with the names used across the author's papers and companion book series, including the acronyms PEVG and PARA, so that the two bodies of work can be cited as one. Version 1.1 names two constructs the specification already contained. The central proposition is named the Boundary Invariant, and the three architectural declarations required of every pattern are together named the BOE Declaration. Neither carries a trademark, both are offered for use with attribution under this document's licence, and neither changes any requirement: the proposition, its wording and its priority date are those of version 1.0. Section 11 gains the two-family naming convention and a precedence rule fixing which document governs where this specification and the Defensible AI Framework Registry describe the same relationship.
The adoption of generative artificial intelligence among communication practitioners and researchers surged after the launch of ChatGPT in November 2022, urging practitioners to critically engage in exploring pathways for fostering socially responsible and environmentally sustainable AI practices.
An engineering whitepaper documenting the construction of Baiyuan GEO Platform (2024–2026), a SaaS system for Generative Engine Optimization. The system helps brands be cited accurately and consistently across ChatGPT, Claude, Gemini, Perplexity, DeepSeek, and 15+ AI platforms. Coverage: seven-dimension AI citation-rate scoring algorithm, AI-Bot-friendly shadow document delivery (AXP) on customer-owned domains, Schema.org three-layer entity knowledge graph, closed-loop hallucination detection & auto-remediation, F12 three-layer structural optimizer (V1 rule-based + V3.1 dual-engine AutoGEO + E-GEO), rag-backend-v2 LLM hallucination hardening (six defense layers), and platform SSOT chain (brand_faq / page_type / alerts unification). v1.1.2 (this version): substantially expanded chapters 14, 15, 16 in both Traditional Chinese (zh-TW) and English (en) editions — added new sections covering early hand-tuning failure modes, bidirectional rollback design, placeholder guard trigger story, patch order causal chain analysis, cross-tenant cache privacy boundary, breadcrumb 404 ghost incident review (42 days, ~3000 ghost URLs), cross-microservice SSOT boundaries, and 5 engineering lessons (takeaways) per chapter — totaling ~13,000 additional words across 6 chapter files. Also adds LinkedIn launch announcement drafts (4 versions: zh-TW/en/ja personal + zh-TW company). v1.2.0 (this version): adds Part VI — three new chapters (Ch 17 cross-border China GEO with a Hong Kong edge node, UA routing, ICP-free central compliance and bidirectional AI visibility; Ch 18 AXP HTML Mirror-First semantic-HTML shadow documents; Ch 19 a five-layer cache-invalidation architecture for zero-touch propagation) in Traditional Chinese and English; backfills the Japanese edition to full parity (ja chapters 14–19 added); and expands Ch 13 (multimodal GEO) across all three languages with VideoObject GSC parity + origin backfill, a same-origin copyright filter, and sitemap image/video extensions. Languages: Traditional Chinese, English, and Japanese — all complete through chapter 19. License: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0).
Vincent Lin· Zenodo (CERN European Organi...· 3 citations
The deflated-Welch statistic: a closed-form, guaranteed-level test for heteroscedastic one-way ANOVA William J. Dwyer, MD, MPH, FAAP — Department of Mathematics and Statistics, University of Massachusetts Lowell. ORCID 0009-0004-0855-7222. Concept DOI (always resolves to the latest version): 10.5281/zenodo.21908169. What this is The reproducibility deposit for the deflated-Welch statistic T_BB, a closed-form, guaranteed-level test for heteroscedastic one-way ANOVA (the Behrens–Fisher problem for k ≥ 3 groups). Welch's test becomes liberal under skew and unstable variance weights at small samples; T_BB = Q(s²)·exp(−R) keeps the ordinary group means and buys a guaranteed level by deflating the Welch quadratic by a Berger–Boos scale-inflation radius R. Three operating points are provided: a fixedcalibrated radius (κ_s), a design-adaptive near-guarantee radius (closed-form polygamma Cornish–Fisher with a finite-nkurtosis guard), and a fully proved smallest-eigenvalue radius R_eig (Gaussian, extended under bounded kurtosis). What the deposit contains Manuscript (author + anonymized) and a derivations supplement (DA1–DA13) plus a long-form derivations companion, covering: why Welch fails under skew in closed form; the Berger–Boos deflation and its exact worst-case radius; the polygamma-cumulant Cornish–Fisher radius with saddlepoint-exact normal backbone; the excess-kurtosis tail term with its finite-n upper-confidence guard; the imbalance correction; the fully proved smallest-eigenvalue radius (with the k-group multiplicity fix, free-β optimization, and the proved-under-bounded-kurtosis widening); and the k-sample Behrens–Fisher null distribution. Interactive demonstrator rerun_cochran/honest_anova.html — computes raw-mean Welch, the fixed / adaptive / proved T_BB radii, the estimand-changing transform routes, and the full routing receipt in the browser, reproducing the deposited Python. Its engine is extracted as a standalone Node module (m01A_anova_engine.js) and checked cell-by-cell against Python across an 84-design taxonomy (verify_anova_engine_taxonomy.py/.js, max |Δp| = 0.00000). Reproducibility scripts (rerun_cochran/, rerun/) — every reported number traces to a named, deterministically-seeded script (size/power/surface, the calibration and information-limit decompositions, the proved-radius verification, the imbalance calibration, the skew-router branch, and the figures). Real-data evidence — anova_flip_scan.py scans 2,783 public one-way layouts (254 datasets): guaranteed T_BBwithholds ~41% of Welch-significant calls, concentrated where the weight-instability screen fires, and never manufactures significance (Table 7 / Figure 15). Figures and the deterministic deposit builder (fixed timestamps → stable md5). All evaluation is simulation-based; the one empirical component is the public-dataset scan, which uses only openly distributed data. Code is released under the MIT License; text and figures under CC BY 4.0. Version history (consolidated changelog) Published version DOIs are marked ✅; the concept DOI above always resolves to the latest. Staged versions were rolled into the next published one unless noted. v1.0.77 ✅ 10.5281/zenodo.22167690 (2026-08-30): CSDA guide-for-authors conformance — abstract trimmed to 247 words (from 284), keywords cut to 7 (from 11), the withholding highlight shortened to ≤85 characters, and the arXiv PDF/source regenerated. No change to methods, results, figures, or code. v1.0.76 ✅ 10.5281/zenodo.22167536 (2026-08-30) — AI-disclosure heading aligned to Elsevier. The manuscript's declaration heading is now "Declaration of generative AI and AI-assisted technologies in the manuscript preparation process" (was "Use of generative AI"); the disclosure body is unchanged. Prepared alongside an Elsevier-compliant cover-letter variant and an EM suggested-reviewer sheet (both kept outside the deposit). docx/pdf rebuilt; deterministic md5 refreshed. v1.0.75 ✅ 10.5281/zenodo.22167304 (2026-08-30) — Submission-sharpening pass. Graphical abstract + Elsevier Highlights; figures and tables renumbered into reading order with per-table Source clauses; the validity–power frontier (Figure 8) now carries the proved R_eig operating point (100% validity, size-adjusted power 0.613, merge_tbb_proved_frontier.py); new Section 7 "Recovering power by design" + Table 8 (rc_anova_power_by_design.py); and a live required-n calculator in honest_anova.html (per-group and total n for 80% power, "power now @ total n"), with a numeric-heading CSS fix and the engine re-verified against Python at 0.00000. v1.0.74 ✅ 10.5281/zenodo.22165892 (2026-08-29) — Proved-under-bounded-kurtosis radius (DA12.6). The proved non-normal widening now keys on excess kurtosis, √(1 + κ̂·(n−1)/(2n)), from the exact Var(s²/σ²) = 2/(n−1) + κ/n, so symmetric heavy tails (Student-t) are covered where the old skew form √(1 + 0.75·skew²) under-covered; tbbProvedswitched to the kurtosis form across the demonstrator, engine, and Python truth (re-verified JS-vs-Python at 0.00000); new rc_anova_kurtosis_proof.py + deep-dive. v1.0.73 ✅ 10.5281/zenodo.22165709 (2026-08-29) — Reconstructed & verified demonstrator engine (standalone Node module + taxonomy verifier, max |Δp| = 0.00000 across 84 designs; Yuen zero-variance fix; T_BB-routed presets both directions); series-impact deep-dive (the corrected R_eig k-group multiplicity gap also reaches m03 and m01t). v1.0.72 (2026-08-29) — Title set to "The deflated-Welch statistic…"; corrected + optimized proved radius R_eig (β/k multiplicity fix + β-optimization, DA12); real-data Welch-vs-T_BB flip scan (2,783 layouts; Table 7 / Figure 15) + demonstrator imbalance-factor fix; long-form derivations companion. v1.0.71 / v1.0.70 (2026-08-21) — Zhang normal-reference comparator benchmarked on the efficiency frontier (valid on only 24% of designs, in the calibrated-liberal cluster); k = 2 adaptive-radius case-study fold (design-scaling vs shape-keying distinction). v1.0.69 ✅ 10.5281/zenodo.22035826 (2026-08-20) — HTML R1/R2 presentation pass + Figure 9 adaptive per-cluster label merge. v1.0.68 ✅ 10.5281/zenodo.22033737 (2026-08-20) — Companion consolidation into a single six-column Table 6; Figures 11–14 harmonized into one story. v1.0.67 / v1.0.65 / v1.0.60 (2026-08-19/20) — Guarded-reference naming-collision fix; the 40,000-replication expanded-frontier pin (Table 3 + Figure 8) with the symmetric-heteroscedastic skew-router branch; the mean-preserving lightened-R_eig do-not-use fallback. v1.0.59 ✅ 10.5281/zenodo.21995320 (2026-08-18) — Reporting standard + honest_anova.html demonstrator re-aligned to the current T_BB methods paper. v1.0.57 ✅ 10.5281/zenodo.21986847 (2026-08-17) — Reviewer-comprehension pass (multi-paragraph abstract, contributions list, trimmed captions); proved radius R_eig added as a Table 3 scorecard row; corner tail-index correction (N−k)/2 (low-order moments exist in every deployed design). v1.0.56–v1.0.49 (2026-08-16) — The k-sample Behrens–Fisher corner-distribution program: two-moment scaled-χ² corner reference, derived corner cumulants, the secular-eigenvalue law + closed CGF + power-law tail, consolidated into derivations DA13 with a prior-art/novelty audit. v1.0.48 ✅ 10.5281/zenodo.21963458 (2026-08-16) — The unifying λ(z) correction (a smooth instability-keyed deflation strength). v1.0.45 ✅ 10.5281/zenodo.21962965 (2026-08-16) — Atomic sparsity index + bootstrap-t edge hardening + shape-aware pooled standardized-residual bootstrap (SA-PSRB); multivariate transfer to m03. v1.0.44–v1.0.41 (2026-08-16) — Shape-moment re-injection order (skew is the sweet spot), validated and hardened pooled standardized-residual bootstrap, atomic weight-noise probes. v1.0.40 ✅ 10.5281/zenodo.21961667 (2026-08-16) — Log-domain weight-stabilization probe (negative for stabilization; clarifies the size-adjusted oracle ceiling); includes the oracle-power gap decomposition (≈92% conservatism, ≈8% estimation). v1.0.37 ✅ 10.5281/zenodo.21961327 (2026-08-16) — Residual-bootstrap qualification of the shoot-out + the first proved Gaussian smallest-eigenvalue radius R_eig (DA12, the p = 1 specialization of the m03 theorem). v1.0.36 (2026-08-15) — Figure 11 T_BB-region colour fix (amber, matching the routing figures). v1.0.27 ✅ 10.5281/zenodo.21908170 — Earlier published baseline of the deposit. Provenance: every number traces to a named, deterministically-seeded script listed in the manuscript Declarations; the demonstrator engine reproduces the deposited Python to max |Δp| = 0.00000 across the taxonomy verification. License. Code and scripts in the deposit are released under the MIT License; text and figures under CC BY 4.0. Reuse is permitted with attribution to the author and citation of the concept DOI above. How to cite. Dwyer, W. J. The deflated-Welch statistic: a closed-form, guaranteed-level test for heteroscedastic one-way ANOVA. Reproducibility deposit, Zenodo. https://doi.org/10.5281/zenodo.21908169
William Dwyer· Zenodo (CERN European Organi...· 2 citations
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
“GeoPT” helps AI models understand the basics of physics so they can simulate how objects respond to things like wind and water more efficiently and accurately.
