Loss of function of LprG-Rv1410c and MmpL11 homologues in Mycobacterium smegmatis leads to altered glycopeptidolipid profile and decreased cellular c-di-GMP levels during biofilm formation
While both LprG-Rv1410c and MmpL11 pathways are involved in modulating cellular c-di-GMP levels during biofilm formation, only LprG-Rv1410c are important for regulating GPL synthesis and/or surface localization, and MmpL11 may play a broad role in fine-tuning GPL levels.
Introduction Glycopeptidolipids (GPLs) are major constituents of the cell envelope of non-tuberculous mycobacteria (NTM) and play essential roles in colony morphology, surface motility, biofilm formation, antimicrobial susceptibility, and host–pathogen interactions. Although the GPL biosynthetic locus has been extensiv...
M. Della Gala, R. Marasco, I. De Chiara et al.· Frontiers in Microbiology· 0 citations
These findings establish PPE57 as an essential accessory component of the MmpL3 lipid transport system, bridging mycobacterial cell wall assembly with host nutrient exploitation during persistent infection.
Results indicate that smi1 not only participates in cell wall biosynthesis and morphological regulation in M. purpureus, but also potentially regulates the synthesis of MPs and citrinin by affecting central and secondary metabolic networks.
Yu-Lian Li, Qing Liu, Yi-Ming Deng et al.· International Journal of Bio...· 0 citations
It is shown that gp48 encoded by mycobacteriophage Adephagia is toxic when overexpressed in Mycobacterium smegmatis and Mycobacterium abscessus and the toxicity results from gp48 interaction with the host mannose-1-phosphate guanylyltransferase (Mpg) enzyme.
Michael J. Lauer, K. Freeman, Da Jiang et al.· bioRxiv· 0 citations
EspF-TRIM25-NLRP3 axis is a novel mechanism of mycobacterial pathogenesis that drives hyperinflammation to facilitate bacterial survival and dissemination.
Yang Yang, Yi-Xin Han, Long-Jian Wu et al.· Virulence· 0 citations
Mycobacterial-derived lipid-linked galactan (LLG) is an essential component of the Mycobacterial tuberculosis (Mtb) cell wall core arabinogalactan (AG), a well-established virulence factor and target of anti-tubercular drugs. Cross-membrane translocation of LLG is energetically unfavorable and is therefore catalyzed by...
Chuan-Cun Wei, Katherine A. Abrahams, Violetta Krisilia et al.· Nature Communications· 0 citations
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